Smith S A, Stoner J E, Russell A E, Sheppard J M, Aylward P E
Department of Medicine, Flinders Medical Centre, Bedford Park, South Australia.
Br Heart J. 1989 Apr;61(4):344-7. doi: 10.1136/hrt.61.4.344.
The effect of a two minute cold pressor test on transmitral velocities measured by pulsed Doppler was studied in 11 healthy volunteers. Blood pressure increased significantly during cold immersion but peak atrial and peak early diastolic transmitral velocities and their ratio (A:E) were unchanged. There was no correlation between changes in Doppler variables and changes in calculated mean arterial blood pressure during the test. Heart rate changes were variable and not related to changes in blood pressure. In individual people the change in pulse interval during cold immersion was significantly and inversely correlated with the change in the A:E ratio. The large acute increase in arterial pressure seen during the cold pressor test in normal volunteers had no consistent effect on the transmitral velocity profile although small changes in heart rate were associated with large changes in A:E ratio. The effect of small changes in heart rate may be of considerable importance in determining transmitral velocity profiles. Thus in clinical and experimental studies in which the heart rate is not controlled, Doppler data on transmitral flow should be interpreted with caution.
在11名健康志愿者中研究了两分钟冷加压试验对经脉冲多普勒测量的二尖瓣血流速度的影响。冷浸过程中血压显著升高，但心房峰值和舒张早期二尖瓣峰值血流速度及其比值（A:E）未发生变化。试验期间，多普勒变量的变化与计算得出的平均动脉血压变化之间无相关性。心率变化不定，且与血压变化无关。在个体中，冷浸期间脉搏间期的变化与A:E比值的变化显著负相关。正常志愿者在冷加压试验中出现的动脉压大幅急性升高，对二尖瓣血流速度曲线没有一致的影响，尽管心率的微小变化与A:E比值的大幅变化相关。心率的微小变化在确定二尖瓣血流速度曲线方面可能具有相当重要的意义。因此，在心率未得到控制的临床和实验研究中，应谨慎解读二尖瓣血流的多普勒数据。
