Mayet J, Shahi M, Foale R A, Poulter N R, Sever P S, McG Thom S A
Department of Cardiology, St Mary's Hospital Medical School, London.
BMJ. 1994 Apr 16;308(6935):1011-4. doi: 10.1136/bmj.308.6935.1011.
To assess racial differences in cardiac structure and function in patients presenting with previously untreated hypertension.
Untreated black patients with hypertension were compared with untreated white patients matched for age and sex. Both groups had similar body mass indices, blood pressures, and reported duration of hypertension.
Cardiovascular risk factor clinic for outpatients.
36 men and 22 women with untreated essential hypertension.
Variables of heart structure and function on cross sectional and Doppler echocardiography.
The black patients had a significantly greater interventricular septal thickness (mean 1.23 (95% confidence interval 1.14 to 1.33) v 1.09 (1.02 to 1.16) cm; P = 0.02) and posterior wall thickness (mean 1.14 (1.07 to 1.22) v 0.96 (0.88 to 1.03) cm; P = 0.001) than the white patients, although left ventricular internal diameter was not significantly different (mean 4.90 (4.68 to 5.12) v 4.82 (4.64 to 5.01) cm; P = 0.59). This resulted in a significantly greater left ventricular mass index (mean 151 (137 to 164) v 120 (107 to 133) g/m2; P = 0.001) and relative wall thickness (mean 0.47 (0.43 to 0.51) v 0.40 (0.37 to 0.42) cm; P = 0.004) in the black patients. Comparison of Doppler measures of left ventricular diastolic function showed a significantly longer isovolumic relaxation time in black patients (mean 107 (98 to 116) v 92 (83 to 101) ms; P = 0.02) compared with white patients, although peak early to atrial filling ratios were similar in both groups (mean 1.14 (0.95 to 1.32) v 1.04 (0.94 to 1.15); P = 0.37).
Among previously untreated hypertensive patients, black subjects compared with white subjects have significantly higher left ventricular mass index and relative wall thickness, as well as more impairment of left ventricular function during diastole.
评估初治高血压患者心脏结构和功能的种族差异。
将未接受治疗的高血压黑人患者与年龄和性别相匹配的未接受治疗的白人患者进行比较。两组患者的体重指数、血压和报告的高血压病程相似。
门诊心血管危险因素诊所。
36名男性和22名女性初治原发性高血压患者。
横断面和多普勒超声心动图检查的心脏结构和功能变量。
黑人患者的室间隔厚度（平均1.23（95%置信区间1.14至1.33）对1.09（1.02至1.16）cm；P = 0.02）和后壁厚度（平均1.14（1.07至1.22）对0.96（0.88至1.03）cm；P = 0.001）显著高于白人患者，尽管左心室内径无显著差异（平均4.90（4.68至5.12）对4.82（4.64至5.01）cm；P = 0.59）。这导致黑人患者的左心室质量指数（平均151（137至164）对120（107至133）g/m²；P = 0.001）和相对壁厚度（平均0.47（0.43至0.51）对0.40（0.37至0.42）cm；P = 0.004）显著更高。比较左心室舒张功能的多普勒测量结果显示，与白人患者相比，黑人患者的等容舒张时间显著更长（平均107（98至116）对92（83至101）ms；P = 0.02），尽管两组的早期峰值与心房充盈率相似（平均1.14（0.95至1.32）对1.04（0.94至1.15）；P = 0.37）。
在初治高血压患者中，与白人受试者相比，黑人受试者的左心室质量指数和相对壁厚度显著更高，舒张期左心室功能受损也更严重。
