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A benefit-risk assessment of the use of proton pump inhibitors in the elderly.质子泵抑制剂在老年人中的使用的获益-风险评估。
Drugs Aging. 2014 Apr;31(4):263-82. doi: 10.1007/s40266-014-0166-4.
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National growth in intensive care unit admissions from emergency departments in the United States from 2002 to 2009.美国 2002 年至 2009 年急诊科重症监护病房入院人数的国家增长情况。
Acad Emerg Med. 2013 May;20(5):479-86. doi: 10.1111/acem.12134.
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Prescribing patterns of proton pump inhibitors in older hospitalized patients in a Scottish health board.苏格兰某卫生委员会中，老年住院患者质子泵抑制剂的处方模式。
Geriatr Gerontol Int. 2013 Oct;13(4):1002-9. doi: 10.1111/ggi.12047. Epub 2013 Mar 19.
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Overutilization of proton-pump inhibitors: what the clinician needs to know.质子泵抑制剂的过度使用：临床医生需要了解的知识。
Therap Adv Gastroenterol. 2012 Jul;5(4):219-32. doi: 10.1177/1756283X12437358.
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Inappropriate prescribing of proton pump inhibitors in older patients: effects of an educational strategy.不适当的质子泵抑制剂处方在老年患者中的应用：教育策略的效果。
Drugs Aging. 2012 Aug 1;29(8):681-90. doi: 10.1007/BF03262283.
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Proton pump inhibitors and risk of fractures: a meta-analysis of 11 international studies.质子泵抑制剂与骨折风险：11 项国际研究的荟萃分析。
Am J Med. 2011 Jun;124(6):519-26. doi: 10.1016/j.amjmed.2011.01.007.
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Prevalence and appropriateness of drug prescriptions for peptic ulcer and gastro-esophageal reflux disease in a cohort of hospitalized elderly.住院老年患者中消化性溃疡和胃食管反流病药物处方的流行情况和适宜性。
Eur J Intern Med. 2011 Apr;22(2):205-10. doi: 10.1016/j.ejim.2010.11.009. Epub 2010 Dec 21.
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Metformin and digestive disorders.二甲双胍与消化道疾病。
Diabetes Metab. 2011 Apr;37(2):90-6. doi: 10.1016/j.diabet.2010.11.002. Epub 2011 Jan 13.
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Use of acid-suppressive drugs and risk of pneumonia: a systematic review and meta-analysis.抑酸药物的使用与肺炎风险：系统评价和荟萃分析。
CMAJ. 2011 Feb 22;183(3):310-9. doi: 10.1503/cmaj.092129. Epub 2010 Dec 20.
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Overuse of PPIs in patients at admission, during treatment, and at discharge in a tertiary Spanish hospital.西班牙一家三级医院中患者在入院时、治疗期间及出院时质子泵抑制剂的过度使用情况。
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老年患者的多种疾病与质子泵抑制剂的过度处方

Multimorbidities and Overprescription of Proton Pump Inhibitors in Older Patients.

作者信息

Delcher Anne, Hily Sylvie, Boureau Anne Sophie, Chapelet Guillaume, Berrut Gilles, de Decker Laure

机构信息

Department of Geriatrics, Saint-Nazaire Hospital, Saint-Nazaire, France.

Department of Geriatrics, Nantes University Hospital, Nantes, France.

出版信息

PLoS One. 2015 Nov 4;10(11):e0141779. doi: 10.1371/journal.pone.0141779. eCollection 2015.

DOI:10.1371/journal.pone.0141779
PMID:26535585
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4633104/
Abstract

OBJECTIVES

To determine whether there is an association between overprescription of proton pump inhibitors (PPIs) and multimorbidities in older patients.

DESIGN

Multicenter prospective study.

SETTING

Acute geriatric medicine at the University Hospital of Nantes and the Hospital of Saint-Nazaire.

PARTICIPANTS

Older patients aged 75 and over hospitalized in acute geriatric medicine.

MEASUREMENTS

Older patients in acute geriatric medicine who received proton pump inhibitors. Variables studied were individual multimorbidities, the burden of multimorbidity evaluated by the Cumulative Illness Rating Scale, age, sex, type of residence (living in nursing home or not), functional abilities (Lawton and Katz scales), nutritional status (Body Mass Index), and the type of concomitant medications (antiaggregant, corticosteroids', or anticoagulants).

RESULTS

Overprescription of proton pump inhibitors was found in 73.9% older patients. In the full model, cardiac diseases (odds ratio [OR] = 4.17, p = 0.010), metabolic diseases (OR = 2.14, p = 0.042) and corticosteroids (OR = 5.39, p = 0.028) were significantly associated with overprescription of proton pump inhibitors. Esogastric diseases (OR = 0.49, p = 0.033) were negatively associated with overprescription of proton pump inhibitors.

CONCLUSION

Cardiac diseases and metabolic diseases were significantly associated with overprescription of proton pump inhibitors.

摘要

目的

确定老年患者质子泵抑制剂（PPI）过度处方与多种疾病并存之间是否存在关联。

设计

多中心前瞻性研究。

地点

南特大学医院和圣纳泽尔医院的急性老年医学科。

参与者

75岁及以上因急性老年医学疾病住院的老年患者。

测量指标

接受质子泵抑制剂治疗的急性老年医学科老年患者。研究的变量包括个体多种疾病、用累积疾病评分量表评估的多种疾病负担、年龄、性别、居住类型（是否住在养老院）、功能能力（Lawton和Katz量表）、营养状况（体重指数）以及伴随用药类型（抗血小板药、皮质类固醇或抗凝剂）。

结果

73.9%的老年患者存在质子泵抑制剂过度处方情况。在完整模型中，心脏病（比值比[OR]=4.17，p=0.010）、代谢性疾病（OR=2.14，p=0.042）和皮质类固醇（OR=5.39，p=0.028）与质子泵抑制剂过度处方显著相关。食管胃部疾病（OR=0.49，p=0.033）与质子泵抑制剂过度处方呈负相关。

结论

心脏病和代谢性疾病与质子泵抑制剂过度处方显著相关。