白细胞介素-17基因多态性在胃癌易感性中的作用。

Role of IL-17 gene polymorphisms in the susceptibility to gastric cancer.

作者信息

Qi W T, Gao J L, Zhang S S

机构信息

Department of Emergency, Zhengzhou People's Hospital, Zhengzhou, China.

Department of Internal Medicine, Zhengzhou Straight Authority Hospital, Zhengzhou, China.

出版信息

Genet Mol Res. 2015 Oct 27;14(4):13364-9. doi: 10.4238/2015.October.26.33.

DOI:10.4238/2015.October.26.33

PMID:26535650

Abstract

We conducted a study to investigate the role of three IL-17 gene single nucleotide polymorphisms (SNP) (rs2275913G>A, rs3748067C>T, and rs763780 T>C) in the development of gastric cancer. A total of 252 patients with gastric cancer and 252 control subjects were collected between May 2012 and May 2014. The SNP genotyping of IL-17A rs2275913G>A and rs3748067C>T and IL-17F rs763780 T>C was performed using the Sequenom MassARRAY platform (Sequenom, San Diego, CA, USA) according to the manufacturer instructions. By conditional regression analysis, individuals carrying the AA and the GA+AA genotypes of rs2275913G>A were correlated with an elevated risk of gastric cancer when compared with those carrying the GG genotype, and the adjusted ORs (95%CIs) were 2.05 (1.13-3.76) for the AA genotype and 1.45 (1.03-2.08) for the GA+AA genotype. In conclusion, our results suggest that the IL-17A rs3748067C>T and IL-17F rs763780 T>C polymorphisms play an important role in the risk of gastric cancer in a Chinese population.

摘要

我们开展了一项研究，以调查白细胞介素-17（IL-17）基因的三个单核苷酸多态性（SNP）（rs2275913G>A、rs3748067C>T和rs763780 T>C）在胃癌发生发展中的作用。2012年5月至2014年5月期间，共收集了252例胃癌患者和252例对照受试者。根据制造商说明，使用Sequenom MassARRAY平台（美国加利福尼亚州圣地亚哥的Sequenom公司）对IL-17A的rs2275913G>A和rs3748067C>T以及IL-17F的rs763780 T>C进行SNP基因分型。通过条件回归分析，与携带GG基因型的个体相比，携带rs2275913G>A的AA和GA+AA基因型的个体患胃癌的风险升高，AA基因型的校正比值比（95%置信区间）为2.05（1.13 - 3.76），GA+AA基因型为1.45（1.03 - 2.08）。总之，我们的结果表明，IL-17A的rs3748067C>T和IL-17F的rs763780 T>C多态性在中国人群胃癌风险中起重要作用。