Principi Nicola, Esposito Susanna
a Pediatric Highly Intensive Care Unit, Department of Pathophysiology and Transplantation , Università degli Studi di Milano, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico , Milan , Italy.
Expert Rev Respir Med. 2015;9(6):711-9. doi: 10.1586/17476348.2015.1109451. Epub 2015 Nov 4.
The outbreak of Enterovirus D-68 (EV-D68) in the United States in 2014 raised great interest due to it affecting large numbers of people and because patients presented with severe respiratory and/or central nervous system involvement. Many studies have tried to evaluate the biologic and genetic characteristics of this virus, its association with disease development and the possibility of infection prevention and therapy. The main aim of this paper is to discuss what is presently known and what might be expected in the future regarding EV-D68. We highlight that further studies are needed to precisely define the epidemiology and total burden of EV-D68, the real age prevalence, and the factors that may lead to negative outcomes in some patients and not in others. Moreover, if recently reported clinical data are confirmed, specific efficacious prophylactic and therapeutic measures should be urgently developed.
2014年肠道病毒D68（EV-D68）在美国爆发，因其感染了大量人群，且患者出现严重的呼吸系统和/或中枢神经系统受累情况，引发了极大关注。许多研究试图评估这种病毒的生物学和遗传学特征、其与疾病发展的关联以及感染预防和治疗的可能性。本文的主要目的是讨论目前已知的关于EV-D68的情况以及未来可能预期的情况。我们强调，需要进一步研究以精确界定EV-D68的流行病学和总体负担、实际年龄患病率，以及可能导致部分患者出现不良后果而部分患者未出现的因素。此外，如果最近报告的临床数据得到证实，应紧急制定具体有效的预防和治疗措施。
