University of Colorado School of Medicine, Department of Pediatrics, Section of Infectious Disease.
Section of Hospital Medicine, Aurora, CO 80045.
Microbiol Spectr. 2016 Jun;4(3). doi: 10.1128/microbiolspec.EI10-0018-2016.
Enterovirus-D68 (EV-D68) is a unique enterovirus, similar to human rhinoviruses, spread via the respiratory route and primarily causing respiratory disease. Increasing clusters of EV-D68 associated respiratory disease have been reported since 2008, with the largest reported outbreak occurring in North America in 2014. Epidemiologic data and biological plausibility support an association of EV-D68 with the neurologic condition, acute flaccid myelitis. Diagnosis requires EV-D68 specific PCR or viral sequencing of respiratory specimens. Treatment consists of supportive care, as there are no currently available effective vaccines or antiviral therapies. Further research is needed to prepare for future EV-D68 outbreaks of respiratory or neurologic disease.
肠道病毒 D68（EV-D68）是一种独特的肠道病毒，类似于人类鼻病毒，通过呼吸道传播，主要引起呼吸道疾病。自 2008 年以来，越来越多的与肠道病毒 D68 相关的呼吸道疾病集群报告，2014 年在北美发生了最大规模的报告暴发。流行病学数据和生物学合理性支持肠道病毒 D68 与神经状况急性弛缓性脊髓炎有关。诊断需要肠道病毒 D68 特异性 PCR 或呼吸道标本的病毒测序。治疗包括支持性护理，因为目前尚无有效的疫苗或抗病毒疗法。需要进一步研究为未来肠道病毒 D68 引起的呼吸道或神经系统疾病暴发做好准备。
