Wu San-Gang, Rao Ming-Yue, Zhou Juan, Lin Qin, Wang Zi-Jing, Chen Yong-Xiong, He Zhen-Yu
Department of Radiation Oncology, Xiamen Cancer Center, the First Affiliated Hospital of Xiamen University, Xiamen, People's Republic of China.
Department of Radiology, the First Affiliated Hospital of Xiamen University, Xiamen, People's Republic of China.
Oncotarget. 2015 Dec 22;6(41):44030-6. doi: 10.18632/oncotarget.5828.
This study aimed to investigate the patterns of brain metastasis and to explore the risk factors affecting hippocampus metastasis (HM). We retrospectively analyzed the clinical information of patients with metastatic disease in the brain. The associations between clinicopathologic variables with HM and peri-hippocampal metastasis (PHM) were evaluated in univariate and multivariate regression analyses. A total of 632 patients with 6064 metastatic lesions were recruited into the present study. Of these, 4.1% (26/632) of patients developed HM, and 5.5% (35/632) of patients developed PHM. Only 0.5% (31/6064) of metastatic lesions were located in the hippocampus and 0.6% (37/6064) were in the PHM. Age ≤60 years was an independent risk factor for HM (odds ratio [OR]: 2.602, 95% confidence interval [CI]: 1.115-6.076, P = 0.027) and PHM (OR: 2.555, 95%CI: 1.229-5.310, P = 0.012) in univariate and multivariate analyses. The hippocampus is a rare site of brain metastasis. Younger patients (age ≤60 years) had increased risk of developing HM and PHM. The current study provides the opportunity to investigate the clinical feasibility of hippocampal sparing whole brain radiation therapy, especially in older patients.
本研究旨在调查脑转移模式，并探索影响海马转移（HM）的危险因素。我们回顾性分析了脑转移瘤患者的临床信息。在单因素和多因素回归分析中评估了临床病理变量与HM及海马旁转移（PHM）之间的关联。本研究共纳入632例患者，有6064个转移灶。其中，4.1%（26/632）的患者发生HM，5.5%（35/632）的患者发生PHM。仅0.5%（31/6064）的转移灶位于海马，0.6%（37/6064）位于PHM。在单因素和多因素分析中，年龄≤60岁是HM（比值比[OR]：2.602，95%置信区间[CI]：1.115 - 6.076，P = 0.027）和PHM（OR：2.555，95%CI：1.229 - 5.310，P = 0.012）的独立危险因素。海马是脑转移的罕见部位。年轻患者（年龄≤60岁）发生HM和PHM的风险增加。本研究为探讨保留海马的全脑放射治疗的临床可行性提供了机会，尤其是在老年患者中。
