染色质重塑与转录起始
Chromatin-remodeling and the initiation of transcription.
作者信息
Lorch Yahli, Kornberg Roger D
机构信息
Department of Structural Biology,Stanford University School of Medicine,Stanford,CA 94305,USA.
出版信息
Q Rev Biophys. 2015 Nov;48(4):465-70. doi: 10.1017/S0033583515000116.
PMID:26537406
Abstract
The nucleosome serves as a general gene repressor by the occlusion of regulatory and promoter DNA sequences. Repression is relieved by the SWI/SNF-RSC family of chromatin-remodeling complexes. Research reviewed here has revealed the essential features of the remodeling process.
摘要
核小体通过封闭调控和启动子DNA序列作为一种普遍的基因抑制因子。染色质重塑复合物的SWI/SNF-RSC家族可解除这种抑制作用。此处综述的研究揭示了重塑过程的基本特征。
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