Department of Internal Medicine, Division of Endocrinology, Diabetology, Angiology, Nephrology and Clinical Chemistry, Eberhard Karls University Tübingen, Otfried-Müller-Str. 10, 72076, Tübingen, Germany.
German Center for Diabetes Research (DZD e.V.), Otfried-Müller-Str. 10, 72076, Tübingen, Germany.
Nutr J. 2015 Nov 4;14:117. doi: 10.1186/s12937-015-0076-2.
Ketoacidosis is a potential complication of type 1 diabetes. Severe ketoacidosis with a blood pH below 7.0 is only rarely seen in other diseases.Three weeks after delivery, a young woman was admitted because of tachypnoe and tachycardia. Blood gas analysis showed a severe metabolic acidosis with a high anion gap. Further workup revealed the presence of ketone bodies in the urine with normal blood glucose and no history of diabetes. The patient reported that she had not eaten for days because of abdominal pain. After initial treatment in the ICU and immediate re-feeding, the patient's condition rapidly improved.While under normal circumstances fasting causes at most only mild acidosis, it can be dangerous during lactation. Prolonged fasting in combination with different forms of stress puts breast feeding women at risk for starvation ketoacidosis and should therefore be avoided.
酮症酸中毒是 1 型糖尿病的一种潜在并发症。严重的酮症酸中毒伴有血 pH 值低于 7.0，在其他疾病中很少见。产后 3 周，一名年轻女性因呼吸急促和心动过速入院。血气分析显示严重的代谢性酸中毒，阴离子间隙高。进一步检查发现尿液中有酮体，血糖正常，无糖尿病史。患者报告说，由于腹痛，她已经好几天没吃东西了。在 ICU 进行初步治疗和立即重新喂养后，患者的病情迅速改善。虽然在正常情况下，禁食最多只会导致轻度酸中毒，但在哺乳期却很危险。长时间禁食加上不同形式的压力会使哺乳期妇女面临饥饿性酮症酸中毒的风险，因此应予以避免。
