Giguère S, Weber E J, Sanchez L C
Veterinary Medical Center, University of Georgia, Athens, USA.
Hofmann Neonatal Intensive Care Unit, College of Veterinary Medicine, University of Florida, Gainesville, USA.
Equine Vet J. 2017 Jan;49(1):45-50. doi: 10.1111/evj.12536. Epub 2015 Dec 25.
There is a paucity of information regarding the association between common disorders and outcome over time in a large population of ill equine neonates.
To describe the relative frequency of neonatal disorders in a large population of foals admitted to a neonatal intensive care unit, to determine the disorders and factors associated with nonsurvival and determine if the outcome of ill neonatal foals has improved over time.
Retrospective study.
Cases were selected from equine neonatal (≤14 days of age) admissions between 1982 and 2008. Multivariable logistic regression was used to identify the disorders, clinical parameters and laboratory variables associated with nonsurvival or natural death and assess survival over time after accounting for potential confounding variables.
A total of 1065 foals were included in the study. Overall, 775 of 1065 (72.8%) foals survived to be discharged from the hospital and 290 (27.2%) foals were nonsurvivors. Age at admission, sepsis score, proportion of foals with positive blood cultures and proportion of survivors were significantly different (P<0.001) between primary disease categories. Variables retained in the multivariable model for nonsurvival included positive blood culture, neutrophils <2.28 × 10 /l, temperature ≤37.6°C, bicarbonate, PCO , presence of infectious orthopaedic disorders and sepsis score. The adjusted odds of survival for foals admitted in the 2000s were approximately 3.4 (95% CI = 1.9-6.0, P<0.001) times higher than that of foals admitted in the 1980s.
Primary disorders, sepsis, temperature, acid base status and neutropenia are the main factors that affect outcome in this population of equine neonates. The survival of foals admitted to a neonatal intensive care unit has increased dramatically over a 26 year period.
关于大量患病马驹新生儿常见疾病与长期预后之间的关联，目前信息匮乏。
描述入住新生儿重症监护病房的大量马驹中新生儿疾病的相对频率，确定与非存活相关的疾病和因素，并确定患病新生儿马驹的预后是否随时间有所改善。
回顾性研究。
病例选自1982年至2008年间马驹新生儿（≤14日龄）的入院病例。采用多变量逻辑回归来识别与非存活或自然死亡相关的疾病、临床参数和实验室变量，并在考虑潜在混杂变量后评估长期生存率。
本研究共纳入1065匹马驹。总体而言，1065匹马驹中有775匹（72.8%）存活至出院，290匹（27.2%）马驹未存活。不同主要疾病类别之间，入院时年龄、败血症评分、血培养阳性的马驹比例和存活者比例存在显著差异（P<0.001）。多变量模型中保留的与非存活相关的变量包括血培养阳性、中性粒细胞<2.28×10⁹/l、体温≤37.6°C、碳酸氢盐、PCO₂、感染性骨科疾病的存在以及败血症评分。21世纪入院的马驹的调整后存活几率比20世纪80年代入院的马驹高出约3.4倍（95%置信区间=1.9 - 6.0，P<0.001）。
主要疾病、败血症、体温、酸碱状态和中性粒细胞减少是影响这群马驹新生儿预后的主要因素。在26年期间，入住新生儿重症监护病房的马驹的存活率显著提高。
