Andalib Iman, Shah Hiral, Bal Bikram S, Shope Timothy R, Finelli Frederick C, Koch Timothy R
Department of Medicine, MedStar-Washington Hospital Center and Georgetown University School of Medicine, Washington, DC 20010, USA.
EPGI, Allentown, PA 18104, USA.
Dis Markers. 2015;2015:102760. doi: 10.1155/2015/102760. Epub 2015 Oct 11.
Abdominal symptoms are common after bariatric surgery, and these individuals commonly have upper gut bacterial overgrowth, a known cause of malabsorption. Breath hydrogen determination after oral glucose is a safe and inexpensive test for malabsorption. This study is designed to investigate breath hydrogen levels after oral glucose in symptomatic individuals who had undergone Roux-en-Y gastric bypass surgery.
This is a retrospective study of individuals (n = 63; 60 females; 3 males; mean age 49 years) who had gastric bypass surgery and then glucose breath testing to evaluate abdominal symptoms.
Among 63 postoperative individuals, 51 (81%) had a late rise (≥45 minutes) in breath hydrogen or methane, supporting glucose malabsorption; 46 (90%) of these 51 subjects also had an early rise (≤30 minutes) in breath hydrogen or methane supporting upper gut bacterial overgrowth. Glucose malabsorption was more frequent in subjects with upper gut bacterial overgrowth compared to subjects with no evidence for bacterial overgrowth (P < 0.001).
These data support the presence of intestinal glucose malabsorption associated with upper gut bacterial overgrowth in individuals with abdominal symptoms after gastric bypass surgery. Breath hydrogen testing after oral glucose should be considered to evaluate potential malabsorption in symptomatic, postoperative individuals.
减肥手术后腹部症状很常见，这些个体通常存在上消化道细菌过度生长，这是吸收不良的一个已知原因。口服葡萄糖后测定呼气氢气是一种用于检测吸收不良的安全且廉价的测试方法。本研究旨在调查接受Roux-en-Y胃旁路手术且有症状的个体口服葡萄糖后的呼气氢气水平。
这是一项对接受胃旁路手术并随后进行葡萄糖呼气试验以评估腹部症状的个体（n = 63；60名女性；3名男性；平均年龄49岁）的回顾性研究。
在63名术后个体中，51名（81%）呼气氢气或甲烷出现延迟上升（≥45分钟），支持葡萄糖吸收不良；这51名受试者中有46名（90%）呼气氢气或甲烷也出现早期上升（≤30分钟），支持上消化道细菌过度生长。与无细菌过度生长证据的受试者相比，上消化道细菌过度生长的受试者中葡萄糖吸收不良更为常见（P < 0.001）。
这些数据支持胃旁路手术后有腹部症状的个体存在与上消化道细菌过度生长相关的肠道葡萄糖吸收不良。对于有症状的术后个体，应考虑口服葡萄糖后进行呼气氢气检测以评估潜在的吸收不良情况。
