Corazza G R, Benati G, Strocchi A, Malservisi S, Gasbarrini G
First Department of Medical Pathology, University of Bologna, Italy.
J Lab Clin Med. 1994 Nov;124(5):695-700.
To evaluate the possibility that measurement of breath methane (CH4) enhances the accuracy of breath hydrogen (H2) testing to diagnose carbohydrate malabsorption, breath CH4 concentration of healthy subjects was studied. Fasting breath CH4 concentration measured three times over a 30-minute period in 44 CH4-producing volunteers ranged from 5 to 120 ppm. Fluctuation of breath CH4 excretion exceeded 100% increase over fasting in 1 of 9 subjects who ingested a nonabsorbable, carbohydrate-free solution. Out of 13 subjects who had a false negative breath H2 response to lactulose, 11 had a CH4 percentage increase greater than 100%. In 11 of 32 lactose-intolerant patients with a negative breath H2 test, CH4 percentage increase after lactose challenge was greater than 100%. These data suggested that in methanogenic individuals, breath CH4 measurement might enhance the accuracy of H2 breath testing in detecting carbohydrate malabsorption.
为评估测定呼出气甲烷（CH4）是否能提高呼出气氢气（H2）检测诊断碳水化合物吸收不良的准确性，对健康受试者的呼出气CH4浓度进行了研究。在44名产CH4的志愿者中，于30分钟内三次测量空腹呼出气CH4浓度，范围为5至120 ppm。9名摄入不可吸收、无碳水化合物溶液的受试者中，有1名呼出气CH4排泄波动超过空腹时增加100%。在13名对乳果糖有呼出气H2反应假阴性的受试者中，11名CH4百分比增加超过100%。在32名呼出气H2检测阴性的乳糖不耐受患者中，11名在乳糖激发后CH4百分比增加超过100%。这些数据表明，在产甲烷个体中，呼出气CH4测量可能会提高H2呼气试验检测碳水化合物吸收不良的准确性。
