Goldschmidt P, Cogen R, Taubman S
J Periodontol. 1977 Apr;48(4):212-5. doi: 10.1902/jop.1977.48.4.212.
Exposure of human cells in culture to chlorhexidine at concentrations equal to or greater than 0.004% resulted in impaired cellular function and/or cell death. Release of membrane bound 51Cr, inhibition of protein synthesis as measured by incorporation of 3H-leucine into protein-like material, and staining by trypan blue were seen as sequellae to exposure to 0.006% chlorhexidine for 3 hours. Lower doses were capable of inhibiting protein synthesis and releasing 51Cr, but did not result in staining of cells by trypan blue. Exposure of cells to 0.2% chlorhexidine for 30 seconds produced maximal suppression of protein synthesis and release of 51Cr.
在培养中，将人类细胞暴露于浓度等于或大于0.004%的洗必泰中会导致细胞功能受损和/或细胞死亡。膜结合的51Cr释放、通过将3H-亮氨酸掺入蛋白质样物质来测量的蛋白质合成抑制以及台盼蓝染色，都被视为细胞暴露于0.006%洗必泰3小时后的后遗症。较低剂量能够抑制蛋白质合成并释放51Cr，但不会导致细胞被台盼蓝染色。将细胞暴露于0.2%洗必泰30秒会产生最大程度的蛋白质合成抑制和51Cr释放。
