Paunio K U, Knuttila M, Mielitynen H
J Periodontol. 1978 Feb;49(2):92-5. doi: 10.1902/jop.1978.49.2.92.
The aim of the study was to investigate the effect of chlorhexidine gluconate on the connective tissue formation. Granulation tissue was produced with a method in which sponges were inserted beneath the back skin of rats. Dry sterilized sponges were impregnated either with 0.45% NaCl solution (control) or or 0.2% chlorhexidine solution [test]. The sponges were removed after 3, 5, 7, 10, 14, 19 and 23 days. The content of hydroxyproline, hexosamines, DNA and RNA was estimated from the sponges. The acid glycosaminoglycans were further purified and analyzed. The results of the study indicate that chlorhexidine had a clear delaying effect on the formation of granulation tissue.
本研究的目的是调查葡萄糖酸氯己定对结缔组织形成的影响。采用在大鼠背部皮肤下植入海绵的方法来生成肉芽组织。将干燥灭菌的海绵分别用0.45%氯化钠溶液（对照）或0.2%氯己定溶液[试验组]浸渍。在3、5、7、10、14、19和23天后取出海绵。从海绵中估计羟脯氨酸、己糖胺、DNA和RNA的含量。对酸性糖胺聚糖进行进一步纯化和分析。研究结果表明，氯己定对肉芽组织的形成有明显的延迟作用。
