较低的身体质量指数与巨细胞动脉炎的风险增加相关：系统评价和荟萃分析。
Lower body mass index is associated with a higher risk of giant cell arteritis: a systematic review and meta-analysis.
机构信息
1 Division of Rheumatology, Department of Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA ; 2 Division of Rheumatology, Department of Medicine, Faculty of Medicine Siriraj Hospital, Bangkok, Thailand ; 3 Division of Nephrology and Hypertension, Department of Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA.
出版信息
Ann Transl Med. 2015 Sep;3(16):232. doi: 10.3978/j.issn.2305-5839.2015.09.31.
OBJECTIVE
To characterize the possible association between body mass index (BMI) and risk of giant cell arteritis (GCA).
METHODS
We conducted a systematic review of observational studies (case-control or cohort study) that (I) reported BMI of patients with GCA prior to the diagnosis of GCA compared with subjects without GCA and (II) provided relative risk (RR), odds ratio (OR) or hazard ratio (HR) with 95% confidence interval (CI) from its regression analysis. Meta-analysis of the included studies was then performed to estimate the pooled effect using generic variance method of DerSimonian and Laird.
RESULTS
Three studies encompassing 141 patients with GCA and 85,736 controls met our eligibility criteria and were included in the data analyses. We demonstrated a statistically significant inverse relationship between BMI and risk of subsequent development of GCA as the risk increased by 8% when BMI was reduced by 1.0 kg/m(2) (pooled OR of 0.92/kg/m(2); 95% CI, 0.88-0.96).
CONCLUSIONS
Our study demonstrated a statistically significant inverse relationship between BMI and risk of subsequent development GCA. The pathophysiologic link behind this negative correlation is not well-characterized and further investigation is required.
目的
描述体质指数（BMI）与巨细胞动脉炎（GCA）风险之间可能存在的关联。
方法
我们对观察性研究（病例对照或队列研究）进行了系统回顾，这些研究（I）报告了 GCA 患者在 GCA 诊断前的 BMI 与无 GCA 患者的 BMI 相比，以及（II）提供了相对风险（RR）、比值比（OR）或风险比（HR）及其回归分析的 95%置信区间（CI）。然后对纳入的研究进行荟萃分析，使用 DerSimonian 和 Laird 的通用方差法估计汇总效应。
结果
符合纳入标准并纳入数据分析的有三项研究，共纳入 141 例 GCA 患者和 85736 例对照。我们证明 BMI 与 GCA 发生风险之间存在统计学上显著的负相关关系，当 BMI 降低 1.0kg/m²时，风险增加 8%（汇总 OR 为 0.92/kg/m²；95%CI，0.88-0.96）。
结论
我们的研究表明 BMI 与 GCA 发生风险之间存在统计学上显著的负相关关系。这种负相关背后的病理生理联系尚不清楚，需要进一步研究。
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