南极海绵源真菌 sp. HDN151272 产生的抗菌聚酮类化合物。
Antibacterial Polyketides from Antarctica Sponge-Derived Fungus sp. HDN151272.
机构信息
Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China.
Laboratory for Marine Drugs and Bioproducts, Pilot National Laboratory for Marine Science and Technology, Qingdao 266237, China.
出版信息
Mar Drugs. 2020 Jan 23;18(2):71. doi: 10.3390/md18020071.
Three new polyketides, ketidocillinones A-C (-), were discovered from the extract of an Antarctica sponge-derived fungus sp. HDN151272. All the structures were deduced by spectroscopic data, including NMR and HRESIMS. The absolute configuration of compound was established by using ECD calculation. Compounds - can be slowly oxidized to quinone form when exposed to air. Ketidocillinones B and C ( and ) exhibited potent antibacterial activity against , and MRCNS (methicillin-resistant coagulase-negative ) with MIC values ranging from 1.56 to 25.00 µg/mL.
三种新的聚酮化合物，酮基头霉素 A-C（-），从南极海绵源真菌 sp. HDN151272 的提取物中被发现。所有的结构都是通过光谱数据，包括 NMR 和 HRESIMS 推断出来的。化合物的绝对构型是通过使用 ECD 计算确定的。当暴露在空气中时，化合物-可以缓慢氧化成醌形式。酮基头霉素 B 和 C（和）对、和 MRCNS（耐甲氧西林凝固酶阴性葡萄球菌）表现出强烈的抗菌活性，MIC 值范围为 1.56 至 25.00 µg/mL。
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