Key Laboratory of Marine Drugs, Ministry of Education of China, School of Medicine and Pharmacy; Institute of Evolution & Marine Biodiversity, Ocean University of China, Qingdao 266003, People's Republic of China.
College of Pharmaceutical Sciences, Hebei University, Baoding 071002, People's Republic of China.
J Nat Prod. 2020 Apr 24;83(4):1300-1304. doi: 10.1021/acs.jnatprod.0c00144. Epub 2020 Apr 3.
Microketides A and B ( and ), a pair of new C-11 epimeric polyketides, were obtained from the gorgonian-derived fungus sp. RA10-14 collected from the South China Sea. The absolute configurations of and were assigned by the modified Mosher's method, TDDFT-ECD, and NMR calculations. Compounds and were evaluated for antibacterial, antifungal, and growth inhibition of marine phytoplankton activities. Microketide A () exhibited promising inhibitory activity against , , , and with the same MIC value as ciprofloxacin (0.19 μg/mL).
微酮 A 和 B（和）是一对新的 C-11 差向异构聚酮，从南海采集的柳珊瑚来源真菌 sp. RA10-14 中获得。通过改良的 Mosher 法、TDDFT-ECD 和 NMR 计算确定了和的绝对构型。对化合物和进行了抗菌、抗真菌和海洋浮游植物生长抑制活性评价。微酮 A（）对、、、和表现出有希望的抑制活性，与环丙沙星（0.19μg/mL）的 MIC 值相同。
