Yang Dan, Yang Guixin, Gai Shili, He Fei, An Guanghui, Dai Yunlu, Lv Ruichan, Yang Piaoping
Key Laboratory of Superlight Materials and Surface Technology, Ministry of Education, College of Material Science and Chemical Engineering, Harbin Engineering University, Harbin, 150001, P. R. China.
Nanoscale. 2015 Dec 14;7(46):19568-78. doi: 10.1039/c5nr06192j.
Near-infrared (NIR) light-induced cancer therapy has gained considerable interest, but pure inorganic anti-cancer platforms usually suffer from degradation issues. Here, we designed metal-organic frameworks (MOFs) of Fe3O4/ZIF-8-Au25 (IZA) nanospheres through a green and economic procedure. The encapsulated Fe3O4 nanocrystals not only produce hyperthemal effects upon NIR light irradiation to effectively kill tumor cells, but also present targeting and MRI imaging capability. More importantly, the attached ultrasmall Au25(SR)18(-) clusters (about 2.5 nm) produce highly reactive singlet oxygen ((1)O2) to cause photodynamic effects through direct sensitization under NIR light irradiation. Furthermore, the Au25(SR)18(-) clusters also give a hand to the hyperthemal effect as photothermal fortifiers. This nanoplatform exhibits high biocompatibility and an enhanced synergistic therapeutic effect superior to any single therapy, as verified by in vitro and in vivo assay. This image-guided therapy based on a metal-organic framework may stimulate interest in developing other kinds of metal-organic materials with multifunctionality for tumor diagnosis and therapy.
近红外（NIR）光诱导癌症治疗已引起广泛关注，但纯无机抗癌平台通常存在降解问题。在此，我们通过一种绿色经济的方法设计了Fe3O4/ZIF-8-Au25（IZA）纳米球的金属有机框架（MOF）。包封的Fe3O4纳米晶体不仅在近红外光照射下产生热疗效应以有效杀死肿瘤细胞，还具有靶向和磁共振成像能力。更重要的是，附着的超小Au25（SR）18（-）簇（约2.5纳米）在近红外光照射下通过直接敏化产生高活性单线态氧（（1）O2），从而引起光动力效应。此外，Au25（SR）18（-）簇作为光热增强剂也有助于热疗效应。通过体外和体内实验验证，这种纳米平台具有高生物相容性和优于任何单一疗法的增强协同治疗效果。这种基于金属有机框架的图像引导治疗可能会激发人们对开发其他具有多功能性的金属有机材料用于肿瘤诊断和治疗的兴趣。
