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金纳米团簇在基于光子的癌症治疗中的应用。

Applications of Au Nanoclusters in Photon-Based Cancer Therapies.

作者信息

Lockwood Zoey A, Jirousek Michael R, Basilion James P, Burda Clemens

机构信息

Department of Chemistry, College of Arts and Sciences, Case Western Reserve University, Cleveland, OH 44106, USA.

Department of Radiology, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.

出版信息

Nanomaterials (Basel). 2024 Dec 29;15(1):39. doi: 10.3390/nano15010039.

DOI:10.3390/nano15010039
PMID:39791798
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11722186/
Abstract

Atomically precise gold nanoclusters (AuNCs) exhibit unique physical and optical properties, making them highly promising for targeted cancer therapy. Their small size enhances cellular uptake, facilitates rapid distribution to tumor tissues, and minimizes accumulation in non-target organs compared to larger gold nanoparticles. AuNCs, particularly Au, show significant potential in phototherapy, including photothermal (PTT), photodynamic (PDT), and radiation therapies. These therapies benefit with minimal damage to surrounding healthy tissue. AuNCs also demonstrate excellent stability and biocompatibility, crucial for their effective use in clinical applications. Recent advances in the synthesis and functionalization of AuNCs have further improved their therapeutic efficacy, making them versatile agents for enhancing cancer treatment outcomes. Ongoing research aims to better understand their pharmacokinetics, biodistribution, and long-term safety, paving the way for their broader application in advanced cancer therapies.

摘要

原子精确的金纳米团簇（AuNCs）具有独特的物理和光学性质，使其在靶向癌症治疗方面极具前景。与较大的金纳米颗粒相比，它们的小尺寸增强了细胞摄取，促进了向肿瘤组织的快速分布，并使在非靶器官中的积累最小化。AuNCs，特别是金，在光疗中显示出巨大潜力，包括光热疗法（PTT）、光动力疗法（PDT）和放射疗法。这些疗法对周围健康组织的损伤最小。AuNCs还表现出出色的稳定性和生物相容性，这对它们在临床应用中的有效使用至关重要。AuNCs合成和功能化方面的最新进展进一步提高了它们的治疗效果，使其成为增强癌症治疗效果的多功能药物。正在进行的研究旨在更好地了解它们的药代动力学、生物分布和长期安全性，为它们在先进癌症治疗中的更广泛应用铺平道路。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de7d/11722186/59e7c86bcf6a/nanomaterials-15-00039-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de7d/11722186/63807a691366/nanomaterials-15-00039-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de7d/11722186/9c1b645b6a9d/nanomaterials-15-00039-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de7d/11722186/906e6c7866e1/nanomaterials-15-00039-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de7d/11722186/023a945ad542/nanomaterials-15-00039-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de7d/11722186/1394be4bcae0/nanomaterials-15-00039-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de7d/11722186/33280adafbb1/nanomaterials-15-00039-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de7d/11722186/b88d4ff0f875/nanomaterials-15-00039-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de7d/11722186/be38531f79ec/nanomaterials-15-00039-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de7d/11722186/9dcb012cac04/nanomaterials-15-00039-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de7d/11722186/59e7c86bcf6a/nanomaterials-15-00039-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de7d/11722186/63807a691366/nanomaterials-15-00039-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de7d/11722186/9c1b645b6a9d/nanomaterials-15-00039-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de7d/11722186/906e6c7866e1/nanomaterials-15-00039-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de7d/11722186/023a945ad542/nanomaterials-15-00039-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de7d/11722186/1394be4bcae0/nanomaterials-15-00039-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de7d/11722186/33280adafbb1/nanomaterials-15-00039-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de7d/11722186/b88d4ff0f875/nanomaterials-15-00039-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de7d/11722186/be38531f79ec/nanomaterials-15-00039-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de7d/11722186/9dcb012cac04/nanomaterials-15-00039-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de7d/11722186/59e7c86bcf6a/nanomaterials-15-00039-g010.jpg

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