患有胎儿酒精谱系障碍的儿童成年后会怎样？
What Happens When Children with Fetal Alcohol Spectrum Disorders Become Adults?
作者信息
Moore Eileen M, Riley Edward P
机构信息
Center for Behavioral Teratology, San Diego State University, San Diego, CA 92120.
出版信息
Curr Dev Disord Rep. 2015 Sep;2(3):219-227. doi: 10.1007/s40474-015-0053-7. Epub 2015 Jun 24.
Abstract
The range of structural abnormalities and functional deficits caused by prenatal alcohol exposure (PAE) are referred to as fetal alcohol spectrum disorders (FASDs). The disabilities associated with FASDs are said to be lifelong, but we know relatively little regarding outcomes beyond childhood and adolescence. Many of physical, brain, and neurobehavioral features that are present in children with FASDs will endure to adulthood. However, some features may diminish or change over time. Furthermore, secondary disabilities, such as school drop outs, trouble with the law, and substance/alcohol abuse problems are common in young adults with FASDs. The health consequences associated with PAE in the human adult are unknown, but animal models suggest that they may be more susceptible to chronic diseases such as hypertension, diabetes, immune dysfunction, and cancer. More research is needed to understand the lasting effects of PAE on adults and the developmental trajectories of FASDs.
摘要
产前酒精暴露（PAE）所导致的一系列结构异常和功能缺陷被称为胎儿酒精谱系障碍（FASDs）。据说与FASDs相关的残疾是终身的，但我们对儿童期和青春期之后的结果了解相对较少。FASDs儿童所具有的许多身体、大脑和神经行为特征会持续到成年期。然而，一些特征可能会随着时间的推移而减弱或改变。此外，继发性残疾，如辍学、触犯法律以及药物/酒精滥用问题，在患有FASDs的年轻人中很常见。PAE对成年人类的健康影响尚不清楚，但动物模型表明，他们可能更容易患慢性疾病，如高血压、糖尿病、免疫功能障碍和癌症。需要更多的研究来了解PAE对成年人的长期影响以及FASDs的发展轨迹。
相似文献
1
What Happens When Children with Fetal Alcohol Spectrum Disorders Become Adults?患有胎儿酒精谱系障碍的儿童成年后会怎样？
Curr Dev Disord Rep. 2015 Sep;2(3):219-227. doi: 10.1007/s40474-015-0053-7. Epub 2015 Jun 24.
2
The Association of the Hypothalamic-Pituitary-Adrenal Axis with Appetite Regulation in Children with Fetal Alcohol Spectrum Disorders (FASDs).下丘脑-垂体-肾上腺轴与胎儿酒精谱系障碍（FASD）儿童食欲调节的关系。
Nutrients. 2023 Mar 11;15(6):1366. doi: 10.3390/nu15061366.
3
Improving Recognition of Children Affected by Prenatal Alcohol Exposure: Detection of Exposure in Pediatric Care.提高对受产前酒精暴露影响儿童的识别：在儿科护理中检测暴露情况。
Curr Dev Disord Rep. 2015 Sep 1;2(3):165-174. doi: 10.1007/s40474-015-0057-3.
4
Fetal Alcohol Spectrum Disorders: What Pediatric Providers Need to Know.胎儿酒精谱系障碍：儿科医疗服务提供者需要了解的内容。
J Pediatr Health Care. 2017 Sep-Oct;31(5):594-606. doi: 10.1016/j.pedhc.2017.04.002.
5
Psychiatric conditions associated with prenatal alcohol exposure.与产前酒精暴露相关的精神疾病。
Dev Disabil Res Rev. 2009;15(3):225-34. doi: 10.1002/ddrr.74.
6
Listening Difficulties in Children With Fetal Alcohol Spectrum Disorders: More Than a Problem of Audibility.儿童酒精谱系障碍的听力障碍：不仅仅是可听度问题。
J Speech Lang Hear Res. 2019 May 21;62(5):1532-1548. doi: 10.1044/2018_JSLHR-H-18-0359.
7
Neurodevelopmental Trajectories Following Prenatal Alcohol Exposure.产前酒精暴露后的神经发育轨迹
Front Hum Neurosci. 2022 Jan 4;15:695855. doi: 10.3389/fnhum.2021.695855. eCollection 2021.
8
Intervention for individuals with fetal alcohol spectrum disorders: treatment approaches and case management.胎儿酒精谱系障碍个体的干预措施：治疗方法与病例管理
Dev Disabil Res Rev. 2009;15(3):258-67. doi: 10.1002/ddrr.67.
9
Hospitalizations and mortality among patients with fetal alcohol spectrum disorders: a prospective study.胎儿酒精谱系障碍患者的住院和死亡情况：一项前瞻性研究。
Sci Rep. 2020 Nov 11;10(1):19512. doi: 10.1038/s41598-020-76406-6.
10
Randomized, double-blind, placebo-controlled clinical trial of choline supplementation in school-aged children with fetal alcohol spectrum disorders.针对患有胎儿酒精谱系障碍的学龄儿童补充胆碱的随机、双盲、安慰剂对照临床试验。
Am J Clin Nutr. 2016 Dec;104(6):1683-1692. doi: 10.3945/ajcn.116.142075. Epub 2016 Nov 2.
引用本文的文献
1
Comorbidities associated with fetal alcohol spectrum disorders in the United States.美国与胎儿酒精谱系障碍相关的合并症。
Sci Rep. 2025 Aug 13;15(1):29704. doi: 10.1038/s41598-025-13366-9.
2
Preventing exclusionary discipline and adverse life experiences in FASD: Teachers' ability to recognize students with FASD in the classroom and develop and implement preventative strategies to support learning and behavior.预防胎儿酒精谱系障碍（FASD）中的排他性纪律处分和不良生活经历：教师在课堂上识别患有FASD的学生并制定和实施支持学习与行为的预防策略的能力。
Alcohol Clin Exp Res (Hoboken). 2025 Aug;49(8):1828-1838. doi: 10.1111/acer.70100. Epub 2025 Jun 16.
3
Feasibility trial of the My Health Coach app for adults with fetal alcohol spectrum disorders.针对患有胎儿酒精谱系障碍的成年人的“我的健康教练”应用程序可行性试验。
Res Dev Disabil. 2025 May 31;164:105053. doi: 10.1016/j.ridd.2025.105053.
4
Thalamic Nuclear Volumes in Fetal Alcohol Spectrum Disorders: from Adolescence to Middle-Age 20 Years Later.胎儿酒精谱系障碍中的丘脑核体积：20年后从青春期到中年期
Biol Psychiatry Cogn Neurosci Neuroimaging. 2025 Apr 18. doi: 10.1016/j.bpsc.2025.04.002.
5
Impact of Neuroimmune System Activation by Adolescent Binge Alcohol Exposure on Adult Neurobiology.青少年暴饮酒精暴露激活神经免疫系统对成年神经生物学的影响。
Adv Exp Med Biol. 2025;1473:179-208. doi: 10.1007/978-3-031-81908-7_9.
6
Prenatal Alcohol Exposure Disrupts CXCL16 Expression in Rat Hippocampus: Temporal and Sex Differences.产前酒精暴露会破坏大鼠海马体中的CXCL16表达：时间和性别差异。
Int J Mol Sci. 2025 Feb 23;26(5):1920. doi: 10.3390/ijms26051920.
7
Identifying family environment profiles in families of children with prenatal alcohol exposure.识别产前酒精暴露儿童家庭的家庭环境概况。
Alcohol Clin Exp Res (Hoboken). 2025 Apr;49(4):771-782. doi: 10.1111/acer.70016. Epub 2025 Mar 11.
8
Embryoid Body Test: A Simple and Reliable Alternative Developmental Toxicity Test.胚状体试验：一种简单可靠的替代性发育毒性试验。
Int J Mol Sci. 2024 Dec 18;25(24):13566. doi: 10.3390/ijms252413566.
9
Prenatal Alcohol Exposure and Transient Systemic Hypoxia-Ischemia Result in Subtle Alterations in Dendritic Complexity in Medial Frontal Cortical Neurons in Juvenile and Young Adult Rat Offspring in a Pilot Study.一项初步研究表明，产前酒精暴露和短暂性全身缺氧缺血会导致幼年和年轻成年大鼠后代内侧前额叶皮质神经元树突复杂性出现细微变化。
Cells. 2024 Nov 30;13(23):1983. doi: 10.3390/cells13231983.
10
Exploring Nutritional Status and Metabolic Imbalances in Children with FASD: A Cross-Sectional Study.探讨 FASD 患儿的营养状况和代谢失衡：一项横断面研究。
Nutrients. 2024 Oct 7;16(19):3401. doi: 10.3390/nu16193401.
本文引用的文献
1
Diagnosing FASD in adults: the development and operation of an adult FASD clinic in Ontario, Canada.成人胎儿酒精谱系障碍的诊断：加拿大安大略省一家成人胎儿酒精谱系障碍诊所的发展与运营
J Popul Ther Clin Pharmacol. 2015;22(1):e96-e105.
2
Cognitive and executive functions, social cognition and sense of coherence in adults with fetal alcohol syndrome.患有胎儿酒精综合征的成年人的认知与执行功能、社会认知及连贯感
Nord J Psychiatry. 2015 Aug;69(6):472-8. doi: 10.3109/08039488.2015.1009487. Epub 2015 Feb 20.
3
Psychosocial outcomes of fetal alcohol syndrome in adulthood.成人胎儿酒精综合征的社会心理结局。
Pediatrics. 2015 Jan;135(1):e52-8. doi: 10.1542/peds.2014-1915. Epub 2014 Dec 22.
4
Child psychiatry branch of the National Institute of Mental Health longitudinal structural magnetic resonance imaging study of human brain development.美国国立精神卫生研究所儿童精神病学分支对人类大脑发育的纵向结构磁共振成像研究。
Neuropsychopharmacology. 2015 Jan;40(1):43-9. doi: 10.1038/npp.2014.236. Epub 2014 Sep 8.
5
Triglycerides and cardiovascular disease.甘油三酯与心血管疾病。
Lancet. 2014 Aug 16;384(9943):626-635. doi: 10.1016/S0140-6736(14)61177-6.
6
Effects of prenatal alcohol exposure on the development of white matter volume and change in executive function.孕期酒精暴露对白质体积发育及执行功能变化的影响。
Neuroimage Clin. 2014 Jun 4;5:19-27. doi: 10.1016/j.nicl.2014.05.010. eCollection 2014.
7
Validation of the fetal alcohol spectrum disorder (FASD) 4-Digit Diagnostic Code.胎儿酒精谱系障碍（FASD）四位数字诊断编码的验证
J Popul Ther Clin Pharmacol. 2013;20(3):e416-67. Epub 2013 Nov 15.
8
Fetal alcohol spectrum disorders and childhood cancer: a concise review of case reports and future research considerations.胎儿酒精谱系障碍与儿童癌症：病例报告简要综述及未来研究考虑因素。
Pediatr Blood Cancer. 2014 May;61(5):768-70. doi: 10.1002/pbc.24886. Epub 2013 Nov 30.
9
Physiologic frailty as a sign of accelerated aging among adult survivors of childhood cancer: a report from the St Jude Lifetime cohort study.生理脆弱是儿童癌症成年幸存者加速衰老的标志：来自圣裘德终身队列研究的报告。
J Clin Oncol. 2013 Dec 20;31(36):4496-503. doi: 10.1200/JCO.2013.52.2268. Epub 2013 Nov 18.
10
Aging in rare intellectual disability syndromes.罕见智力残疾综合征中的衰老
Dev Disabil Res Rev. 2013;18(1):75-83. doi: 10.1002/ddrr.1130.
Zotero 插件