Metser Ur, Lo Glen
Joint Department of Medical Imaging, University Health Network, Mount Sinai Hospital and Women's College Hospital, University of Toronto, Toronto, ON, Canada.
Br J Radiol. 2016;89(1057):20150844. doi: 10.1259/bjr.20150844. Epub 2015 Nov 6.
Post-transplant lymphoproliferative disease (PTLD) is a major cause of morbidity and mortality following both solid organ and haematopoietic stem cell transplantation. PTLD has a broad range of manifestations with extranodal involvement more common in the abdomen than nodal involvement. Fludeoxyglucose positron emission tomography/CT (FDG-PET/CT) is sensitive and specific to detect PTLD and can upstage or detect occult PTLD compared with conventional CT imaging. As functional imaging, FDG-PET/CT also has a role in monitoring treatment response. In this pictorial essay, we will discuss the role of FDG-PET/CT in the diagnosis and staging of abdominal PTLD and describe the advantages of functional imaging in assessing response to therapy.
移植后淋巴细胞增生性疾病（PTLD）是实体器官移植和造血干细胞移植后发病和死亡的主要原因。PTLD有广泛的表现，结外受累在腹部比淋巴结受累更常见。氟脱氧葡萄糖正电子发射断层扫描/计算机断层扫描（FDG-PET/CT）对检测PTLD敏感且特异，与传统CT成像相比，可使PTLD分期升高或检测出隐匿性PTLD。作为功能成像，FDG-PET/CT在监测治疗反应方面也有作用。在这篇影像论文中，我们将讨论FDG-PET/CT在腹部PTLD诊断和分期中的作用，并描述功能成像在评估治疗反应中的优势。
