Usui A, Kato K, Abe T, Murase M, Tanaka M, Takeuchi E
Department of Thoracic Surgery, Nagoya University School of Medicine, Japan.
Jpn Circ J. 1989 Feb;53(2):95-100. doi: 10.1253/jcj.53.95.
By using a recently developed highly sensitive enzyme immunoassay method, concentrations of the 3 forms of cytoplasmic creatine kinases (CK-BB, CK-MB and CK-MM) were determined in blood samples serially taken from 18 patients who received mitral valve replacement. Blood CK-BB levels, 0.64 +/- 0.32 ng/ml at the beginning of anesthesia, rose sharply after reperfusion reaching the peak level (23.3 +/- 7.56 ng/ml) 2 hours after reperfusion, and then fell rapidly. The response of CK-BB in blood was rapider and more sensitive than that of CK-MB or CK-MM. The CK-BB concentrations were significantly higher in coronary sinus samples than in arterial samples. These results suggest that the major portion of elevated blood CK-BB level in the early phase after reperfusion are derived from the heart muscle.
通过使用最近开发的一种高灵敏度酶免疫测定方法，对18例接受二尖瓣置换术患者连续采集的血样中3种形式的细胞质肌酸激酶（CK - BB、CK - MB和CK - MM）浓度进行了测定。血CK - BB水平在麻醉开始时为0.64±0.32 ng/ml，再灌注后急剧上升，在再灌注后2小时达到峰值水平（23.3±7.56 ng/ml），然后迅速下降。血中CK - BB的反应比CK - MB或CK - MM更快、更敏感。冠状窦样本中的CK - BB浓度明显高于动脉样本。这些结果表明，再灌注后早期血CK - BB水平升高的主要部分源自心肌。
