Sun Jiehao, Zhou Riyong, Lin Wendong, Zhou Jiahao, Wang Weijan
Department of Anesthesiology, 1st Affiliated Hospital, Wenzhou Medical University, Wenzhou, China.
Department of Anesthesiology, 1st Affiliated Hospital, Wenzhou Medical University, Wenzhou, China.
Clin Ther. 2016 Jan 1;38(1):31-8. doi: 10.1016/j.clinthera.2015.10.011. Epub 2015 Nov 3.
Propofol injection can cause distressing pain, and no method can inhibit it completely. Neither lidocaine nor magnesium sulfate (MgSO4) was sufficient to prevent pain from the injection of propofol. This prospective, double-blind, placebo-controlled study was designed to investigate the efficacy of the MgSO4 plus lidocaine on suppressing propofol injection pain.
Three hundred women received 300 mg MgSO4 (Group M), 40 mg lidocaine (Group L), or 300 mg MgSO4 plus 40 mg lidocaine (Group M+L). This was followed by administration of 50 mg propofol. Pain scores, behavior-related responses, and diameter of the vein were recorded following the injection of propofol.
Patients in Group M + L had lower pain scores. Patients' behavior-related responses in Group M + L were also better compared with the other groups. There were no differences in pain scores between Group L and Group M. The target vein diameter change in Group M and Group M + L was more obvious than in Group L.
Administration of 300 mg MgSO4 plus 40 mg lidocaine reduces propofol injection pain very well. No complications were observed in the treatment groups.
丙泊酚注射可引起令人痛苦的疼痛，且尚无方法能完全抑制。利多卡因和硫酸镁（MgSO4）都不足以预防丙泊酚注射引起的疼痛。本前瞻性、双盲、安慰剂对照研究旨在探讨硫酸镁加利多卡因抑制丙泊酚注射疼痛的疗效。
300名女性分别接受300mg硫酸镁（M组）、40mg利多卡因（L组）或300mg硫酸镁加40mg利多卡因（M+L组）。随后给予50mg丙泊酚。注射丙泊酚后记录疼痛评分、行为相关反应和静脉直径。
M+L组患者的疼痛评分较低。与其他组相比，M+L组患者的行为相关反应也更好。L组和M组之间的疼痛评分没有差异。M组和M+L组的目标静脉直径变化比L组更明显。
给予300mg硫酸镁加40mg利多卡因能很好地减轻丙泊酚注射疼痛。治疗组未观察到并发症。
