N-myc和L-myc基因在小鼠中的染色体定位。
Chromosomal location of N-myc and L-myc genes in the mouse.
作者信息
Campbell G R, Zimmerman K, Blank R D, Alt F W, D'Eustachio P
机构信息
Department of Biochemistry, NYU Medical Center, New York 10016.
出版信息
Oncogene Res. 1989;4(1):47-54.
The myc family of proto-oncogenes consists of at least three members, whose expression is tightly and co-ordinately regulated. The genes are nevertheless dispersed to three distinct chromosomal sites in humans. We have now used somatic cell genetics and the analysis of restriction fragment length polymorphisms (RFLPs) to identify and chromosomally map two mouse N-myc loci, to chromosomes 12 and 5, and two L-myc loci, provisionally to chromosomes 4 and 12. The second locus in each pair may be a pseudogene.
原癌基因的 myc 家族至少由三个成员组成，其表达受到严格且协调的调控。然而，这些基因在人类中分散于三个不同的染色体位点。我们现在利用体细胞遗传学和限制性片段长度多态性（RFLP）分析，将两个小鼠 N - myc 基因座分别定位到 12 号和 5 号染色体上，将两个 L - myc 基因座暂时定位到 4 号和 12 号染色体上。每对中的第二个基因座可能是一个假基因。
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