使用重组近交系和贝叶斯定理进行三位点连锁分析。
Three-locus linkage analysis using recombinant inbred strains and Bayes' theorem.
作者信息
Neumann P E
机构信息
Department of Neurology, Children's Hospital, Boston, Massachusetts.
出版信息
Genetics. 1991 Jul;128(3):631-8. doi: 10.1093/genetics/128.3.631.
Abstract
Recombinant inbred (RI) strains are useful in linkage analysis and gene mapping. However, the generally small number of strains in an RI strain set limits the power of RI strains in linkage detection. Several methods for increasing the power of RI strains have been used, including summing data across RI strain sets and excluding linkage to genomic regions. In this paper, Bayesian analysis is applied to three-locus linkage data. This method further increases the power of RI strains to detect linkage and gives estimations of the probability of each of the three possible gene orders if the test locus is linked to the pair of marker loci. Several examples are presented, including reconsideration of the position of the proto-oncogene L-myc on the mouse linkage map.
摘要
重组近交（RI）系在连锁分析和基因定位中很有用。然而，RI系集合中通常数量较少的品系限制了RI系在连锁检测中的效能。已经使用了几种提高RI系效能的方法，包括汇总不同RI系集合的数据以及排除与基因组区域的连锁。在本文中，贝叶斯分析被应用于三位点连锁数据。该方法进一步提高了RI系检测连锁的效能，并在测试位点与一对标记位点连锁时给出了三种可能基因顺序中每种顺序的概率估计。文中给出了几个例子，包括对原癌基因L-myc在小鼠连锁图谱上位置的重新考量。
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本文引用的文献
1
Inbreeding and Linkage.
Genetics. 1931 Jul;16(4):357-74. doi: 10.1093/genetics/16.4.357.
2
Location of Ly-7 on mouse chromosome 12.
Immunogenetics. 1984;19(6):539-43. doi: 10.1007/BF00403445.
3
Strategies for multilocus linkage analysis in humans.
Proc Natl Acad Sci U S A. 1984 Jun;81(11):3443-6. doi: 10.1073/pnas.81.11.3443.
4
Confidence limits for estimates of gene linkage based on analysis of recombinant inbred strains.
J Hered. 1985 Nov-Dec;76(6):436-40. doi: 10.1093/oxfordjournals.jhered.a110140.
5
Multilocus linkage analysis in humans: detection of linkage and estimation of recombination.
Am J Hum Genet. 1985 May;37(3):482-98.
6
Statistical considerations for linkage analysis using recombinant inbred strains and backcrosses.
Proc Natl Acad Sci U S A. 1986 Mar;83(5):1423-7. doi: 10.1073/pnas.83.5.1423.
7
A linkage map of mouse chromosome 12: localization of Igh and effects of sex and interference on recombination.
Genetics. 1988 Dec;120(4):1073-83. doi: 10.1093/genetics/120.4.1073.
8
Mapping complex genetic traits in humans: new methods using a complete RFLP linkage map.
Cold Spring Harb Symp Quant Biol. 1986;51 Pt 1:49-62. doi: 10.1101/sqb.1986.051.01.007.
9
Chromosomal location of N-myc and L-myc genes in the mouse.
Oncogene Res. 1989;4(1):47-54.
10
A molecular genetic linkage map of mouse chromosome 4 including the localization of several proto-oncogenes.
Genomics. 1989 Nov;5(4):699-709. doi: 10.1016/0888-7543(89)90111-0.
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