Neumann P E
Department of Neurology, Children's Hospital, Boston, Massachusetts.
Genetics. 1991 Jul;128(3):631-8. doi: 10.1093/genetics/128.3.631.
Recombinant inbred (RI) strains are useful in linkage analysis and gene mapping. However, the generally small number of strains in an RI strain set limits the power of RI strains in linkage detection. Several methods for increasing the power of RI strains have been used, including summing data across RI strain sets and excluding linkage to genomic regions. In this paper, Bayesian analysis is applied to three-locus linkage data. This method further increases the power of RI strains to detect linkage and gives estimations of the probability of each of the three possible gene orders if the test locus is linked to the pair of marker loci. Several examples are presented, including reconsideration of the position of the proto-oncogene L-myc on the mouse linkage map.
重组近交（RI）系在连锁分析和基因定位中很有用。然而，RI系集合中通常数量较少的品系限制了RI系在连锁检测中的效能。已经使用了几种提高RI系效能的方法，包括汇总不同RI系集合的数据以及排除与基因组区域的连锁。在本文中，贝叶斯分析被应用于三位点连锁数据。该方法进一步提高了RI系检测连锁的效能，并在测试位点与一对标记位点连锁时给出了三种可能基因顺序中每种顺序的概率估计。文中给出了几个例子，包括对原癌基因L-myc在小鼠连锁图谱上位置的重新考量。
