Bioactive Botanical Research Laboratory, Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island , Kingston, Rhode Island 02881, United States.
The Key Laboratory of Plant Resources and Chemistry of Arid Zone; State Key Laboratory of Xinjiang Indigenous Medicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences , Urumqi 830011, China.
J Agric Food Chem. 2015 Nov 25;63(46):10097-102. doi: 10.1021/acs.jafc.5b04796. Epub 2015 Nov 17.
Cumin (Cuminum cyminum L.), a widely consumed food spice, has been reported to have antiglycative effects in vitro and in vivo, but there is a paucity of data on its bioactive compounds. Herein, we report the isolation and structure elucidation (by NMR, HRESIMS, and CD) of 21 (1-21) compounds from a methanol extract of cumin seeds. The isolates included five new compounds: two sesquiterpenoids, two pairs of monoterpeneoid epimers, and a chalcone, named cuminoids A-E, respectively. The isolates were evaluated for antiglycative effects using the bovine serum albumin-fructose intrinsic fluorescence assay. At equivalent concentrations, several of the isolates, including cuminoids C-E, were more potent inhibitors than the positive control, aminoguanidine, a synthetic antiglycative agent (>50 vs 35%, respectively).
小茴香（Cuminum cyminum L.）是一种广泛食用的香料，据报道具有体外和体内抗糖化作用，但关于其生物活性化合物的数据很少。在此，我们报告了从小茴香种子甲醇提取物中分离和结构鉴定（通过 NMR、HRESIMS 和 CD）的 21 种化合物（1-21）。这些分离物包括五种新化合物：两种倍半萜、两种单萜对映异构体和一种查尔酮，分别命名为小茴香素 A-E。通过牛血清白蛋白-果糖内在荧光测定法评估分离物的抗糖化作用。在等效浓度下，包括小茴香素 C-E 在内的几种分离物比阳性对照物氨基胍（一种合成的抗糖化剂）的抑制作用更强（分别为>50%和 35%）。
