Suppr超能文献

通过募集不同程度定向分化的神经元在三角涡虫中形成记忆

Memory Formation in Tritonia via Recruitment of Variably Committed Neurons.

作者信息

Hill Evan S, Vasireddi Sunil K, Wang Jean, Bruno Angela M, Frost William N

机构信息

Department of Cell Biology and Anatomy, The Chicago Medical School, Rosalind Franklin University of Medicine and Science, 3333 Green Bay Road, North Chicago, IL 60064, USA.

Department of Cell Biology and Anatomy, The Chicago Medical School, Rosalind Franklin University of Medicine and Science, 3333 Green Bay Road, North Chicago, IL 60064, USA.

出版信息

Curr Biol. 2015 Nov 16;25(22):2879-88. doi: 10.1016/j.cub.2015.09.033. Epub 2015 Nov 5.

Abstract

Prior studies have found that functional networks can rapidly add neurons as they build short-term memories, yet little is known about the principles underlying this process. Using voltage-sensitive dye imaging, we found that short-term sensitization of Tritonia's swim motor program involves rapid expansion of the number of participating neurons. Tracking neurons across trials revealed that this involves the conversion of recently discovered variably participating neurons to reliable status. Further, we identify a candidate serotonergic cellular mechanism mediating this process. Our findings reveal a new mechanism for memory formation, involving recruitment of pre-positioned, variably committed neurons into memory networks. This represents a shift from the field's long-term focus on synaptic plasticity, toward a view that certain neurons have characteristics that predispose them to join networks with learning.

摘要

先前的研究发现,功能网络在构建短期记忆时能够迅速增加神经元,但对于这一过程背后的原理却知之甚少。利用电压敏感染料成像技术,我们发现海兔游泳运动程序的短期敏感化涉及参与神经元数量的快速增加。通过追踪不同实验中的神经元,我们发现这一过程涉及将最近发现的可变参与神经元转变为可靠状态。此外,我们确定了一种介导这一过程的候选血清素能细胞机制。我们的研究结果揭示了一种新的记忆形成机制,即招募预先定位的、可变参与的神经元进入记忆网络。这代表了该领域从长期关注突触可塑性,转向认为某些神经元具有使其倾向于通过学习加入网络的特征的观点转变。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f31e/4654661/637ba3620985/nihms724117f1.jpg

相似文献

10
[Brain and memory: new neurons to remember].[大脑与记忆:用于记忆的新神经元]
Biol Aujourdhui. 2015;209(3):229-48. doi: 10.1051/jbio/2015028. Epub 2016 Jan 28.

引用本文的文献

9
Stability of spontaneous, correlated activity in mouse auditory cortex.自发性相关活动在小鼠听觉皮层中的稳定性。
PLoS Comput Biol. 2019 Dec 9;15(12):e1007360. doi: 10.1371/journal.pcbi.1007360. eCollection 2019 Dec.

本文引用的文献

2
The molecular and systems biology of memory.记忆的分子和系统生物学。
Cell. 2014 Mar 27;157(1):163-86. doi: 10.1016/j.cell.2014.03.001.
3
4
The synaptic plasticity and memory hypothesis: encoding, storage and persistence.突触可塑性和记忆假说:编码、存储和持久。
Philos Trans R Soc Lond B Biol Sci. 2013 Dec 2;369(1633):20130288. doi: 10.1098/rstb.2013.0288. Print 2014 Jan 5.
5
Creating a false memory in the hippocampus.在海马体中创造虚假记忆。
Science. 2013 Jul 26;341(6144):387-91. doi: 10.1126/science.1239073.
7
Long-term dynamics of CA1 hippocampal place codes.CA1 海马体位置码的长期动力学。
Nat Neurosci. 2013 Mar;16(3):264-6. doi: 10.1038/nn.3329. Epub 2013 Feb 10.
8
Lifetime memories from persistently supple synapses.持久灵活的突触产生终生记忆。
Hippocampus. 2013 Mar;23(3):202-6. doi: 10.1002/hipo.22088. Epub 2013 Jan 28.
9
Variable neuronal participation in stereotypic motor programs.变异性神经元参与刻板运动程序。
PLoS One. 2012;7(7):e40579. doi: 10.1371/journal.pone.0040579. Epub 2012 Jul 16.
10
Synapses and memory storage.突触与记忆储存。
Cold Spring Harb Perspect Biol. 2012 Jun 1;4(6):a005751. doi: 10.1101/cshperspect.a005751.

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验