对皮肤点刺试验呈阳性的患者进行胭脂红（E120）口服激发试验。
An oral challenge test with carmine red (E120) in skin prick test positive patients.
作者信息
Liippo J, Lammintausta K
机构信息
Department of Dermatology and Allergy Unit, Turku University Hospital and University of Turku, Hämeentie 11, P.O. Box 52, 20520 Turku, Finland. Phone: +358-2-313 1644 E-mail:
Department of Dermatology and Allergy Unit, Turku University Hospital and University of Turku, Turku, Finland.
出版信息
Eur Ann Allergy Clin Immunol. 2015 Nov;47(6):206-10.
BACKGROUND
Positive skin prick test reactions to carmine red (E120) occur in approximately 3% of the patients studied for food allergy. Carmine ingestion associated systemic symptoms are occasionally suspected, but sufficient information of proven carmine allergy is not available.
PATIENTS AND METHODS
To analyse carmine related symptoms in skin prick test positive patients a cohort of 23 patients with suspected allergy to carmine red was subjected to a single-blind placebo-controlled oral challenge test with carmine red.
RESULTS
Five patients developed clinical symptoms during the placebo-controlled oral challenge. As a result, the overall frequency of clinical carmine allergy is estimated to be 0.7% in general dermatology patients studied for food-associated symptoms.
CONCLUSIONS
Oral challenge test provides a valuable in vivo tool to better inform patients with positive skin prick tests to additives to avoid false allergy diets.
背景
在因食物过敏接受研究的患者中，约3%的患者对胭脂红（E120）皮肤点刺试验呈阳性反应。偶尔会怀疑摄入胭脂红会引发全身症状，但尚无关于经证实的胭脂红过敏的充分信息。
患者与方法
为分析皮肤点刺试验呈阳性的患者中与胭脂红相关的症状，对23名疑似对胭脂红过敏的患者进行了一项单盲安慰剂对照的胭脂红口服激发试验。
结果
在安慰剂对照口服激发试验期间，有5名患者出现临床症状。因此，在因食物相关症状接受研究的普通皮肤科患者中，临床胭脂红过敏的总体发生率估计为0.7%。
结论
口服激发试验提供了一种有价值的体内工具，可为皮肤点刺试验呈阳性的添加剂过敏患者提供更多信息，以避免错误的过敏饮食。
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