CD14(+)CD16(+)单核细胞的扩增与急性白血病有关。
Expansion of CD14(+)CD16(+) monocytes is related to acute leukemia.
作者信息
Jiang Xin-Quan, Zhang Lei, Liu Hong-Ai, Yuan Ning, Hou Pei-Qiang, Zhang Rong-Qiang, Wu Tuo
机构信息
Institute of Public Health, Taishan Medical University No.619 Changcheng Road, Taian, Shandong, People's Republic of China.
Clinical Laboratory, Maternity and Child Health Care Hospital District of Dong Chang Fu, Liaocheng, Shandong, People's Republic of China.
出版信息
Int J Clin Exp Med. 2015 Aug 15;8(8):12297-306. eCollection 2015.
OBJECTIVE
Aim to investigate the proportion of CD14(+)CD16(+) monocytes and understand the pathogenesis of this monocyte subset in acute leukemia.
METHODS
Flow cytometry was utilized to study the phenotype expression of CD14(+)CD16(+) monocytes and CD3(+) T lymphocytes in peripheral blood derived from patients with acute leukemia. All the data were analyzed by SPSS 13.0 software.
RESULTS
The proportion of CD14(+)CD16(+) monocytes including both intermediate and non-classical monocytes, increased significantly in patients with acute leukemia and changed negatively or positively according to the disease process. Meanwhile, the proportion of CD14(+)CD16(+) monocytes was inversely correlated with absolute number of CD4(+) T lymphocytes, ratio of CD4(+)/CD8(+) T cells, and positively correlated with the proportion of neutrophil granulocytes.
CONCLUSIONS
The proportion of CD14(+)CD16(+) monocytes (especially the intermediate subpopulation) is related to the progression of acute leukemia, and the expansion of this monocyte subset could indicate the severity of the disease.
目的
旨在研究CD14(+)CD16(+)单核细胞的比例，并了解该单核细胞亚群在急性白血病中的发病机制。
方法
采用流式细胞术研究急性白血病患者外周血中CD14(+)CD16(+)单核细胞和CD3(+)T淋巴细胞的表型表达。所有数据均用SPSS 13.0软件进行分析。
结果
包括中间型和非经典型单核细胞在内的CD14(+)CD16(+)单核细胞比例在急性白血病患者中显著增加，并根据病程呈负向或正向变化。同时，CD14(+)CD16(+)单核细胞比例与CD4(+)T淋巴细胞绝对数、CD4(+)/CD8(+)T细胞比值呈负相关，与中性粒细胞比例呈正相关。
结论
CD14(+)CD16(+)单核细胞（尤其是中间亚群）的比例与急性白血病的进展有关，该单核细胞亚群的扩增可能提示疾病的严重程度。
Zotero 插件