Jenkins D J A, Jones P J, Frohlich J, Lamarche B, Ireland C, Nishi S K, Srichaikul K, Galange P, Pellini C, Faulkner D, de Souza R J, Sievenpiper J L, Mirrahimi A, Jayalath V H, Augustin L S, Bashyam B, Leiter L A, Josse R, Couture P, Ramprasath V, Kendall C W C
Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, ON, Canada; Department of Medicine, Faculty of Medicine, University of Toronto, Toronto, ON, Canada; Clinical Nutrition & Risk Factor Modification Center, St. Michael's Hospital, Toronto, ON, Canada; Division of Endocrinology and Metabolism, St. Michael's Hospital, Toronto, ON, Canada; Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, ON, Canada.
Richardson Center for Functional Foods and Nutraceuticals, University of Manitoba, Winnipeg, MB, Canada.
Nutr Metab Cardiovasc Dis. 2015 Dec;25(12):1132-9. doi: 10.1016/j.numecd.2015.08.006. Epub 2015 Nov 6.
Compared to a DASH-type diet, an intensively applied dietary portfolio reduced diastolic blood pressure at 24 weeks as a secondary outcome in a previous study. Due to the importance of strategies to reduce blood pressure, we performed an exploratory analysis pooling data from intensively and routinely applied portfolio treatments from the same study to assess the effect over time on systolic, diastolic and mean arterial pressure (MAP), and the relation to sodium (Na(+)), potassium (K(+)), and portfolio components.
241 participants with hyperlipidemia, from four academic centers across Canada were randomized and completed either a DASH-type diet (control n = 82) or a dietary portfolio that included, soy protein, viscous fibers and nuts (n = 159) for 24 weeks. Fasting measures and 7-day food records were obtained at weeks 0, 12 and 24, with 24-h urines at weeks 0 and 24. The dietary portfolio reduced systolic, diastolic and mean arterial blood pressure compared to the control by 2.1 mm Hg (95% CI, 4.2 to -0.1 mm Hg) (p = 0.056), 1.8 mm Hg (CI, 3.2 to 0.4 mm Hg) (p = 0.013) and 1.9 mm Hg (CI, 3.4 to 0.4 mm Hg) (p = 0.015), respectively. Blood pressure reductions were small at 12 weeks and only reached significance at 24 weeks. Nuts, soy and viscous fiber all related negatively to change in mean arterial pressure (ρ = -0.15 to -0.17, p ≤ 0.016) as did urinary potassium (ρ = -0.25, p = 0.001), while the Na(+)/K(+) ratio was positively associated (ρ = 0.20, p = 0.010).
Consumption of a cholesterol-lowering dietary portfolio also decreased blood pressure by comparison with a healthy DASH-type diet. CLINICAL TRIAL REG. NO.: NCT00438425, clinicaltrials.gov.
在之前的一项研究中，作为次要结局，与DASH式饮食相比，强化应用的饮食组合在24周时降低了舒张压。鉴于降低血压策略的重要性，我们进行了一项探索性分析，汇总了同一研究中强化和常规应用饮食组合治疗的数据，以评估其随时间对收缩压、舒张压和平均动脉压（MAP）的影响，以及与钠（Na⁺）、钾（K⁺）和饮食组合成分的关系。
来自加拿大四个学术中心的241名高脂血症患者被随机分组，并完成了24周的DASH式饮食（对照组n = 82）或包含大豆蛋白、粘性纤维和坚果的饮食组合（n = 159）。在第0、12和24周获取空腹测量值和7天食物记录，在第0和24周收集24小时尿液。与对照组相比，饮食组合使收缩压、舒张压和平均动脉压分别降低了 2.1 mmHg（95%CI，4.2至 -0.1 mmHg）（p = 0.056）、1.8 mmHg（CI，3.2至0.4 mmHg）（p = 0.013）和1.9 mmHg（CI，3.4至0.4 mmHg）（p = 0.015）。血压在12周时降低幅度较小，仅在24周时达到显著水平。坚果、大豆和粘性纤维与平均动脉压变化均呈负相关（ρ = -0.15至 -0.17，p≤0.016），尿钾也是如此（ρ = -0.25，p = 0.001），而Na⁺/K⁺比值呈正相关（ρ = 0.20，p = 0.010）。
与健康的DASH式饮食相比，食用降胆固醇饮食组合也能降低血压。临床试验注册号：NCT00438425，clinicaltrials.gov。
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