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胸腺肽α1：一种具有免疫活性的胸腺多肽的分离与序列分析

Thymosin alpha1: isolation and sequence analysis of an immunologically active thymic polypeptide.

作者信息

Goldstein A L, Low T L, McAdoo M, McClure J, Thurman G B, Rossio J, Lai C Y, Chang D, Wang S S, Harvey C, Ramel A H, Meienhofer J

出版信息

Proc Natl Acad Sci U S A. 1977 Feb;74(2):725-9. doi: 10.1073/pnas.74.2.725.

DOI:10.1073/pnas.74.2.725
PMID:265536
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC392366/
Abstract

The amino acid sequence of a biologically active polypeptide isolated from calf thymus, termed thymosin alpha1, has been determined. Thymosin alpha1 is a heat stable, highly acidic molecule composed of 28 amino acid residues. This peptide is one of several present in thymosin fraction 5 that may participate in the regulation, differentiation and function of thymus-dependent lymphocytes (T cells). A nomenclature for the family of polypeptides present in thymosin fraction 5 is suggested.

摘要

已确定从牛胸腺中分离出的一种具有生物活性的多肽——胸腺素α1的氨基酸序列。胸腺素α1是一种热稳定的、高度酸性的分子，由28个氨基酸残基组成。该肽是胸腺素5组分中存在的几种可能参与胸腺依赖性淋巴细胞（T细胞）调节、分化和功能的肽之一。本文提出了胸腺素5组分中存在的多肽家族的命名法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5582/392366/a0be13c5910c/pnas00024-0342-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5582/392366/a0be13c5910c/pnas00024-0342-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5582/392366/a0be13c5910c/pnas00024-0342-a.jpg

相似文献

1
Thymosin alpha1: isolation and sequence analysis of an immunologically active thymic polypeptide.胸腺肽α1：一种具有免疫活性的胸腺多肽的分离与序列分析
Proc Natl Acad Sci U S A. 1977 Feb;74(2):725-9. doi: 10.1073/pnas.74.2.725.
2
The chemistry and biology of thymosin. I. Isolation, characterization, and biological activities of thymosin alpha1 and polypeptide beta1 from calf thymus.胸腺素的化学与生物学。I. 从小牛胸腺中分离、鉴定胸腺素α1和多肽β1及其生物学活性。
J Biol Chem. 1979 Feb 10;254(3):981-6.
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The chemistry and biology of thymosin. II. Amino acid sequence analysis of thymosin alpha1 and polypeptide beta1.胸腺素的化学与生物学。II. 胸腺素α1及多肽β1的氨基酸序列分析
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Complete amino acid sequence of bovine thymosin beta 4: a thymic hormone that induces terminal deoxynucleotidyl transferase activity in thymocyte populations.牛胸腺素β4的完整氨基酸序列：一种能诱导胸腺细胞群体中末端脱氧核苷酸转移酶活性的胸腺激素。
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本文引用的文献

1
Electrophoretic mobilities of peptides on paper and their use in the determination of amide groups.肽在纸上的电泳迁移率及其在酰胺基团测定中的应用。
Nature. 1966 Aug 6;211(5049):591-3. doi: 10.1038/211591a0.
2
The estimation of polypeptide chain molecular weights by gel filtration in 6 M guanidine hydrochloride.在6M盐酸胍中通过凝胶过滤法估算多肽链分子量
J Biol Chem. 1969 Sep 25;244(18):4989-94.
3
Acceleration by thymosin of the development of resistance to murine sarcoma virus-induced tumor in mice.胸腺素对小鼠抗鼠肉瘤病毒诱导肿瘤发育的加速作用。
重新利用药物治疗实体瘤：关注免疫检查点抑制剂。
Cancer Biol Med. 2023 Nov 6;20(11):856-68. doi: 10.20892/j.issn.2095-3941.2023.0281.
4
Thymosin α1 and Its Role in Viral Infectious Diseases: The Mechanism and Clinical Application.胸腺肽 α1 及其在病毒感染性疾病中的作用：机制与临床应用。
Molecules. 2023 Apr 17;28(8):3539. doi: 10.3390/molecules28083539.
5
Highlights into historical and current immune interventions for cancer.癌症免疫治疗的历史和现状概述。
Int Immunopharmacol. 2023 Apr;117:109882. doi: 10.1016/j.intimp.2023.109882. Epub 2023 Feb 27.
6
The therapeutic effect of an autologous and allogenic mixed glioma cell lysate vaccine in a rat model.自体与异体混合胶质瘤细胞裂解物疫苗在大鼠模型中的治疗效果。
J Cancer Res Clin Oncol. 2023 Feb;149(2):609-622. doi: 10.1007/s00432-022-04281-x. Epub 2022 Sep 6.
7
PASylated Thymosin α1: A Long-Acting Immunostimulatory Peptide for Applications in Oncology and Virology.PAS 化胸腺肽 α1：一种长效免疫刺激肽，可应用于肿瘤学和病毒学领域。
Int J Mol Sci. 2020 Dec 24;22(1):124. doi: 10.3390/ijms22010124.
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Gender-associated difference following COVID-19 virus infection: Implications for thymosin alpha-1 therapy.新冠病毒感染后的性别相关差异：胸腺肽 α-1 治疗的意义。
Int Immunopharmacol. 2021 Jan;90:107022. doi: 10.1016/j.intimp.2020.107022. Epub 2020 Sep 18.
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Thymosin α1 protects from CTLA-4 intestinal immunopathology.胸腺素 α1 可预防 CTLA-4 肠道免疫病理学。
Life Sci Alliance. 2020 Aug 14;3(10). doi: 10.26508/lsa.202000662. Print 2020 Oct.
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A Reappraisal of Thymosin Alpha1 in Cancer Therapy.癌症治疗中胸腺肽α1的重新评估
Front Oncol. 2019 Sep 6;9:873. doi: 10.3389/fonc.2019.00873. eCollection 2019.
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Reversal by thymosin of increased susceptibility of immunosuppressed mice to Moloney sarcoma virus.胸腺素对免疫抑制小鼠对莫洛尼肉瘤病毒易感性增加的逆转作用。
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Use of fluorescamine in the chromatographic analysis of peptides from proteins.荧光胺在蛋白质来源肽段色谱分析中的应用。
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Proc Natl Acad Sci U S A. 1972 Jul;69(7):1800-3. doi: 10.1073/pnas.69.7.1800.