用胸腺提取物对邓宁白血病进行免疫治疗。
Immunotherapy of the Dunning leukaemia with thymic extracts.
作者信息
Khaw B A, Rule A H
出版信息
Br J Cancer. 1973 Oct;28(4):288-92. doi: 10.1038/bjc.1973.150.
Abstract
Injections of thymic extract (TE), TE primed lymphocytes or normal lymph node cells were effective in bringing about total remission of the Dunning leukaemia in inbred Fisher CD rats. Survival greater than 365 days occurred in 10-80% of the various treated groups whereas untreated leukaemic rats, or leukaemic rats treated with spleen "mock thymus extract" or bovine serum albumin, died within an average of 10-17 days. Administration of antilymphocyte serum into leukaemic rats enhanced their death rate. Stimulation of cell mediated immunity via the production of functional thymus stimulated lymphocytes is postulated as the mechanism by which tumour rejection occurred.
摘要
注射胸腺提取物（TE）、经TE致敏的淋巴细胞或正常淋巴结细胞可有效使近交系Fisher CD大鼠的邓宁白血病完全缓解。在各个治疗组中，10%-80%的大鼠存活时间超过365天，而未治疗的白血病大鼠，或用脾脏“模拟胸腺提取物”或牛血清白蛋白治疗的白血病大鼠，平均在10-17天内死亡。给白血病大鼠注射抗淋巴细胞血清会提高其死亡率。据推测，通过产生功能性胸腺刺激淋巴细胞来刺激细胞介导的免疫是肿瘤排斥发生的机制。
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