Zisblatt M, Goldstein A L, Lilly F, White A
Proc Natl Acad Sci U S A. 1970 Aug;66(4):1170-4. doi: 10.1073/pnas.66.4.1170.
The development of resistance to progressive tumor growth and the effect of a thymic extract upon this developmental process were examined in CBA/Wh mice. Inoculating mice of various ages with murine sarcoma virus (Moloney) permitted the assessment of the period of time postnatally at which the animals developed a threshold level of resistance to progressive tumor growth. Resistance in CBA/Wh mice, at the virus dose used, was first detected at approximately two weeks of age and was completely developed at five weeks.Thymosin, a soluble calf thymic fraction, when administered to neonatal mice beginning on the second day of life, significantly accelerated the rate of development of resistance to progressive tumor growth. The data suggest a humoral role for the thymus in the development of tumor immunity, and that the normal development of cell-mediated immunological competence can be accelerated through the use of thymus-derived extracts.
在CBA/Wh小鼠中研究了对进行性肿瘤生长的抗性发展以及胸腺提取物对这一发育过程的影响。给不同年龄的小鼠接种莫洛尼鼠肉瘤病毒，从而可以评估出生后动物对进行性肿瘤生长产生阈值抗性水平的时间段。在所用病毒剂量下，CBA/Wh小鼠的抗性在大约两周龄时首次被检测到，并在五周龄时完全形成。胸腺素是一种可溶性小牛胸腺提取物，从出生第二天开始给新生小鼠施用时，可显著加速对进行性肿瘤生长抗性的发展速度。数据表明胸腺在肿瘤免疫发展中具有体液作用，并且通过使用胸腺来源的提取物可以加速细胞介导免疫能力的正常发育。
