Ogden Michael W, Marano Kristin M, Jones Bobbette A, Morgan Walter T, Stiles Mitchell F
a RAI Services Company , Winston-Salem, NC , USA and.
b R.J. Reynolds Tobacco Company , Winston-Salem, NC , USA.
Biomarkers. 2015;20(6-7):391-403. doi: 10.3109/1354750X.2015.1094134. Epub 2015 Nov 10.
A randomized, multi-center study of adult cigarette smokers switched to tobacco-heating cigarettes, snus or ultra-low machine yield tobacco-burning cigarettes (50/group) was conducted, and subjects' experience with the products was followed for 24 weeks. Differences in biomarkers of tobacco exposure between smokers and never smokers at baseline and among groups relative to each other and over time were assessed. Results indicated reduced exposure to many potentially harmful constituents found in cigarette smoke following product switching. Findings support differences in exposure from the use of various tobacco products and are relevant to the understanding of a risk continuum among tobacco products (ClinicalTrials.gov Identifier: NCT02061917).
开展了一项针对成年吸烟者的随机多中心研究，这些吸烟者转而使用加热烟草制品、口含烟或超低机器产率的燃烧烟草制品（每组50人），并对受试者使用这些产品的体验进行了24周的跟踪。评估了吸烟者和从不吸烟者在基线时、各群组之间以及随时间推移烟草暴露生物标志物的差异。结果表明，产品转换后，香烟烟雾中发现的许多潜在有害成分的暴露量有所减少。这些发现支持了使用不同烟草制品导致的暴露差异，并且与理解烟草制品之间的风险连续体相关（ClinicalTrials.gov标识符：NCT02061917）。
