IQGAP1是一种磷酸肌醇效应器和激酶支架。
IQGAP1 is a phosphoinositide effector and kinase scaffold.
作者信息
Choi Suyong, Anderson Richard A
机构信息
University of Wisconsin-Madison, School of Medicine and Public Health, 1300 University Avenue, Madison, WI 53706, USA.
University of Wisconsin-Madison, School of Medicine and Public Health, 1300 University Avenue, Madison, WI 53706, USA.
出版信息
Adv Biol Regul. 2016 Jan;60:29-35. doi: 10.1016/j.jbior.2015.10.004. Epub 2015 Oct 28.
Abstract
Phosphatidylinositol 4,5-bisphosphate (PI4,5P2) is a lipid messenger that regulates a wide variety of cellular functions. The majority of cellular PI4,5P2 is generated by isoforms of the type I phosphatidylinositol phosphate kinases (PIPKI) that are generated from three genes, and each PIPKI isoform has a unique distribution and function in cells. It has been shown that the signaling specificity of PI4,5P2 can be determined by a physical association of PIPKs with PI4,5P2 effectors. IQGAP1 is newly identified as an interactor of multiple isoforms of PIPKs. Considering the versatile roles of IQGAP1 in cellular signaling pathways, IQGAP1 may confer isoform-specific roles of PIPKs in distinct cellular locations. In this mini review, the emerging roles of PIPKs that are regulated by an association with IQGAP1 will be summarized. Focuses will be on cell migration, vesicle trafficking, cell signaling, and nuclear events.
摘要
磷脂酰肌醇4,5-二磷酸（PI4,5P2）是一种脂质信使，可调节多种细胞功能。大多数细胞中的PI4,5P2由I型磷脂酰肌醇磷酸激酶（PIPKI）的同工型产生，这些同工型由三个基因产生，并且每种PIPKI同工型在细胞中具有独特的分布和功能。研究表明，PI4,5P2的信号特异性可通过PIPK与PI4,5P2效应器的物理结合来确定。IQGAP1最近被鉴定为多种PIPK同工型的相互作用分子。考虑到IQGAP1在细胞信号通路中的多种作用，IQGAP1可能赋予PIPK在不同细胞位置的同工型特异性作用。在本综述中，将总结与IQGAP1结合而受到调节的PIPK的新作用。重点将放在细胞迁移、囊泡运输、细胞信号传导和核事件上。
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