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基于生物聚合物的布地奈德干粉吸入器的研制：优化、体外沉积及细胞毒性研究。

Development of Budesonide Loaded Biopolymer Based Dry Powder Inhaler: Optimization, In Vitro Deposition, and Cytotoxicity Study.

作者信息

Mali Ashwin J, Pawar Atmaram P, Purohit Ravindra N

机构信息

Department of Pharmaceutics, Poona College of Pharmacy, Bharati Vidyapeeth University, Erandwane, Pune, Maharashtra 411038, India.

出版信息

J Pharm (Cairo). 2014;2014:795371. doi: 10.1155/2014/795371. Epub 2014 Jun 15.

DOI:10.1155/2014/795371
PMID:26556201
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4590799/
Abstract

The progress in the development of DPI technology has boosted the use of sensitive drug molecules for lung diseases. However, delivery of these molecules from conventional DPI to the active site still poses a challenge with respect to deposition efficiency in the lung. At same time, serious systemic side effects of drugs have become a cause for concern. The developed budesonide loaded biopolymer based controlled release DPI had shown maximum in vitro lung deposition with least toxicity. The subject of present study, lactose-free budesonide loaded biopolymer based DPI, further corroborates the great potential of antiasthmatic drugs. This technology is expected to revolutionize the approaches towards enhanced therapeutic delivery of prospective drugs.

摘要

干粉吸入器（DPI）技术的发展进步推动了用于肺部疾病的敏感药物分子的应用。然而，从传统干粉吸入器将这些分子递送至活性部位在肺部的沉积效率方面仍然存在挑战。与此同时，药物严重的全身性副作用已成为令人担忧的问题。已开发的基于载有布地奈德的生物聚合物的控释干粉吸入器在体外肺部沉积方面表现出最大效果且毒性最小。本研究的主题，即基于无乳糖载布地奈德生物聚合物的干粉吸入器，进一步证实了抗哮喘药物的巨大潜力。这项技术有望彻底改变前瞻性药物增强治疗递送的方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dedb/4590799/ed95e7ec5ebd/JPHAR2014-795371.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dedb/4590799/104b0257e6c6/JPHAR2014-795371.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dedb/4590799/2adab343bd31/JPHAR2014-795371.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dedb/4590799/6d5ed1100676/JPHAR2014-795371.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dedb/4590799/ed95e7ec5ebd/JPHAR2014-795371.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dedb/4590799/104b0257e6c6/JPHAR2014-795371.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dedb/4590799/2adab343bd31/JPHAR2014-795371.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dedb/4590799/6d5ed1100676/JPHAR2014-795371.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dedb/4590799/ed95e7ec5ebd/JPHAR2014-795371.007.jpg

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