Chen Zhaojie, Zhang Zhen, Zhang Haiyan, Xie Beibei
Department of Gynaecology, Linyi People's Hospital, Linyi, Shandong 276000, China.
Biomed Res Int. 2015;2015:795656. doi: 10.1155/2015/795656. Epub 2015 Oct 19.
Nonspecific vaginitis (NSV), also named bacterial vaginosis, is one of the most common genital system diseases in women during their reproductive years. The specific pathogenic mechanism of NSV is not clear yet. Upon the balance alteration, large amount of reactive oxidant species (ROS) is generated and accumulated in the genital tract, and thus resulting in oxidative stress, which has been reported to be an important trigger of mitochondrial pathway cell apoptosis. In this study, the antioxidant secretion level and antioxidant enzyme activity in the vaginal discharge were evaluated to analyze the oxidative status in the vaginal tract of NSV patients. The effect of oxidative stress on the vaginal mucosa epithelial cell apoptosis was then studied. The role of oxidative stress on NSV development was uncovered; thus open new direction for the prevention and treatment of NSV by providing antiradical agents was revealed.
非特异性阴道炎（NSV），也称为细菌性阴道病，是育龄期女性最常见的生殖系统疾病之一。NSV的具体致病机制尚不清楚。在平衡改变时，生殖道中会产生并积累大量活性氧（ROS），从而导致氧化应激，据报道氧化应激是线粒体途径细胞凋亡的重要触发因素。在本研究中，评估了阴道分泌物中的抗氧化剂分泌水平和抗氧化酶活性，以分析NSV患者阴道的氧化状态。随后研究了氧化应激对阴道黏膜上皮细胞凋亡的影响。揭示了氧化应激在NSV发展中的作用；从而通过提供抗自由基剂为NSV的预防和治疗开辟了新方向。
