The MOE Key Laboratory of Standardization of Chinese Medicines and SATCM Key Laboratory of New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica (ICMM), Shanghai University of Traditional Chinese Medicine (SHUTCM) , Shanghai 201203, People's Republic of China.
Shanghai R&D Center for Standardization of Chinese Medicines , Shanghai 201203, People's Republic of China.
J Nat Prod. 2017 Jun 23;80(6):1742-1749. doi: 10.1021/acs.jnatprod.6b00972. Epub 2017 May 26.
Nepetaefolins A-J (1-10) and seven known compounds were isolated from the whole plant of Caryopteris nepetaefolia. The absolute configurations of 1-3 were determined from single-crystal X-ray diffraction and spectroscopic data. Compounds 6 and 7, with IC values of 6.3-9.0 μM, showed higher cytotoxicity than paclitaxel in one non-small-cell lung cancer, patient-derived xenograft (PDX) model when tested using PDX models and the adenosine triphosphate-tumor chemosensitivity assay (ATP-TCA).
从丁香假单胞菌全植物中分离得到了 Nepetaefolins A-J（1-10）和七种已知化合物。1-3 的绝对构型是通过单晶 X 射线衍射和光谱数据确定的。化合物 6 和 7 的 IC 值为 6.3-9.0 μM，在使用 PDX 模型和三磷酸腺苷-肿瘤化疗药敏检测（ATP-TCA）进行测试时，在一个非小细胞肺癌患者来源异种移植（PDX）模型中，显示出比紫杉醇更高的细胞毒性。
