State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, People's Republic of China.
J Nat Prod. 2010 Jan;73(1):17-21. doi: 10.1021/np9005579.
Phytochemical investigation of the above-ground parts of Siegesbeckia pubescens yielded 25 diterpenoids, including five new ent-pimarane diterpenoids (1-3, 11, and 12) and four new ent-kaurane diterpenoids (13-16). The structures and relative configurations of the new compounds were elucidated by comprehensive spectroscopic analysis and by comparison of their NMR data with those of related compounds. Single-crystal X-ray diffraction analysis confirmed the structures of 8, 13, and 14. Seven of these diterpenoids were evaluated for cytotoxic activity against HSC-T6, HeLa, and B16 cell lines. Compounds 11 and 14 exhibited moderate cytotoxicity.
地上部分的豨莶草进行了植物化学研究，得到了 25 种二萜类化合物，其中包括 5 种新的表-贝壳杉烷二萜（1-3、11 和 12）和 4 种新的表-贝壳杉烷二萜（13-16）。新化合物的结构和相对构型通过综合光谱分析以及与相关化合物的 NMR 数据比较来阐明。单晶 X 射线衍射分析证实了 8、13 和 14 的结构。这些二萜类化合物中有 7 种对 HSC-T6、HeLa 和 B16 细胞系的细胞毒性活性进行了评估。化合物 11 和 14 表现出中等的细胞毒性。
