在幼仓鼠肾21/C13细胞和二代小鼠胚胎成纤维细胞C57BL/6J中苯并[a]芘-脱氧鸟苷加合物的切除修复
Excision repair of benzo[a]pyrene-deoxyguanosine adducts in baby hamster kidney 21/C13 cells and in secondary mouse embryo fibroblasts C57BL/6J.
作者信息
Shinohara K, Cerutti P A
出版信息
Proc Natl Acad Sci U S A. 1977 Mar;74(3):979-83. doi: 10.1073/pnas.74.3.979.
Abstract
The formation and excision of benzo[a]pyrene-deoxyguanosine adducts in metabolizing baby hamster kidney cells (21/C13) and secondary mouse embryo fibroblasts (C57BL/6J) was investigated. Both diastereomeric adducts, N2-(10-(7beta,8alpha,9alpha-trihydroxy-7, 8, 9, 10 tetrahydrobenzo[a]-7,8,9,10-tetrahydrobenzo[a]pyrene)yl)deoxyguanosine, were detected in both cell lines and both cell lines were capable of excising these lesions, albeit with low efficiency.
摘要
研究了代谢中的幼仓鼠肾细胞（21/C13）和原代小鼠胚胎成纤维细胞（C57BL/6J）中苯并[a]芘-脱氧鸟苷加合物的形成和切除情况。在两种细胞系中均检测到了两种非对映异构体加合物，即N2-（10-（7β，8α，9α-三羟基-7,8,9,10-四氢苯并[a]-7,8,9,10-四氢苯并[a]芘）基）脱氧鸟苷，并且两种细胞系都能够切除这些损伤，尽管效率较低。
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