苯并[a]芘与小鼠和大鼠皮肤DNA的结合。
The binding of benzo[a]pyrene to mouse and rat skin DNA.
作者信息
Baer-Dubowska W, Alexandrov K
出版信息
Cancer Lett. 1981 Jun;13(1):47-52. doi: 10.1016/0304-3835(81)90085-9.
PMID:7306943
Abstract
The covalently bound products of[3H]benzo[a]pyrene (BP) were determined in the DNA from the skin of mice and rats. While the total binding to DNA of rat skin is 3 times less than the DNA of mouse skin, the quality and the distribution of bound products was similar. The formation of (7R)-N2-[10-(7beta, 8alpha, 9alpha-trihydroxy-7,8,9,10-tetrahydrobenzo[a]pyrene)yl] deoxyadenosine ((7R)BPDE I-dA) adduct was found.
摘要
测定了[3H]苯并[a]芘（BP）与小鼠和大鼠皮肤DNA的共价结合产物。虽然大鼠皮肤DNA的总结合量比小鼠皮肤DNA少3倍，但结合产物的质量和分布相似。发现了（7R）-N2-[10-（7β，8α，9α-三羟基-7,8,9,10-四氢苯并[a]芘）基]脱氧腺苷（（7R）BPDE I-dA）加合物的形成。
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