Karataş Mehmet Baran, Şahan Ebru, Özcan Kazım Serhan, Çanga Yiğit, Güngör Barış, Onuk Tolga, İpek Göktürk, Çakıllı Yasin, Arugaslan Emre, Bolca Osman
Siyami Ersek Thoracic and Cardiovascular Surgery Center, Training, Research Hospital Department of Cardiology, Turkey.
Department of Psychiatry, Haydarpaşa Numune Training and Research Hospital, Turkey.
Arq Bras Cardiol. 2015 Oct;105(4):362-70. doi: 10.5935/abc.20150092. Epub 2015 Aug 7.
The relationship between psychiatric illness and heart disease has been frequently discussed in the literature. The aim of the present study was to investigate the relationship between anxiety, depression and overall psychological distress, and coronary slow flow (CSF).
In total, 44 patients with CSF and a control group of 50 patients with normal coronary arteries (NCA) were prospectively recruited. Clinical data, admission laboratory parameters, and echocardiographic and angiographic characteristics were recorded. Symptom Checklist 90 Revised (SCL-90-R), Beck Depression Inventory (BDI), and Beck Anxiety Inventory (BAI) scales were administered to each patient.
The groups were comparable with respect to age, sex, and atherosclerotic risk factors. In the CSF group, BAI score, BDI score, and general symptom index were significantly higher than controls (13 [18.7] vs. 7.5 [7], p = 0.01; 11 [14.7] vs. 6.5 [7], p = 0.01; 1.76 [0.81] vs. 1.1[0.24], p = 0.01; respectively). Patients with CSF in more than one vessel had the highest test scores. In univariate correlation analysis, mean thrombolysis in myocardial infarction (TIMI) frame counts were positively correlated with BAI (r = 0.56, p = 0.01), BDI (r = 0.47, p = 0.01), and general symptom index (r = 0.65, p = 0.01). The psychiatric tests were not correlated with risk factors for atherosclerosis.
Our study revealed higher rates of depression, anxiety, and overall psychological distress in patients with CSF. This conclusion warrants further studies.
精神疾病与心脏病之间的关系在文献中已被频繁讨论。本研究的目的是调查焦虑、抑郁和总体心理困扰与冠状动脉慢血流（CSF）之间的关系。
前瞻性招募了总共44例CSF患者和50例冠状动脉正常（NCA）的对照组患者。记录临床数据、入院实验室参数以及超声心动图和血管造影特征。对每位患者进行症状自评量表90修订版（SCL-90-R）、贝克抑郁量表（BDI）和贝克焦虑量表（BAI）测评。
两组在年龄、性别和动脉粥样硬化危险因素方面具有可比性。CSF组的BAI评分、BDI评分和总体症状指数显著高于对照组（分别为13[18.7]对7.5[7]，p = 0.01；11[14.7]对6.5[7]，p = 0.01；1.76[0.81]对1.1[0.24]，p = 0.01）。多支血管存在CSF的患者测试得分最高。在单变量相关性分析中，心肌梗死溶栓（TIMI）帧数均值与BAI（r = 0.56，p = 0.01）、BDI（r = 0.47，p = 0.01）和总体症状指数（r = 0.65，p = 0.01）呈正相关。精神测试与动脉粥样硬化危险因素无关。
我们的研究显示CSF患者中抑郁、焦虑和总体心理困扰的发生率更高。这一结论有待进一步研究。
