780纳米低强度激光治疗对糖尿病大鼠骨修复的改善作用
Improvement of bone repair in diabetic rats subjected to ƛ780 nm low-level laser therapy.
作者信息
Nascimento Marismar Fernandes do, Almeida Bernadeth Moda de, Cunha John Lennon Silva, Valois Rafael Barreto Vieira, Pinheiro Juliana Campos, Ribeiro Maria Amália Gonzaga, Lima Sonia Oliveira, Albuquerque-Júnior Ricardo Luiz Cavalcanti de
机构信息
Universidade Tiradentes, Aracaju, SE, Brazil.
UNIT, Aracaju, SE, Brazil.
出版信息
Acta Cir Bras. 2015 Oct;30(10):660-7. doi: 10.1590/S0102-865020150100000002.
PURPOSE
To investigate the effect of low-level laser therapy on bone healing in diabetic rats.
METHODS
Bone cavities (19 mm diameter) were performed in the femur of 72 alloxan-induced diabetic rats, which were assigned into four groups: CTR (non-diabetic control), DBT (diabetic) CTRL (non-diabetic irradiated) and DBTL (diabetic irradiated). Low-level laser therapy was performed every 48 h for seven days. Animals were euthanized at seven, 18 and 30 days. Alkaline phosphatase serum levels and bone repair were analyzed.
RESULTS
Low-level laser therapy significantly increased alkaline phosphatase in at seven and 18 days (p<0.001), and improved bone healing at seven (p<0.01), 18 (p<0.05) and 30 (p<0.01) in diabetic animals. In addition, bone healing in irradiated diabetic group was statistically similar to control group at 30 days (p>0.05).
CONCLUSION
Low-level laser therapy increased the serum levels of alkaline phosphatase and improved bone healing in alloxan-induced diabetic rats.
目的
研究低强度激光疗法对糖尿病大鼠骨愈合的影响。
方法
在72只四氧嘧啶诱导的糖尿病大鼠的股骨上制造骨腔（直径19毫米），将其分为四组：CTR（非糖尿病对照组）、DBT（糖尿病组）、CTRL（非糖尿病照射组）和DBTL（糖尿病照射组）。每48小时进行一次低强度激光治疗，持续7天。在第7、18和30天对动物实施安乐死。分析血清碱性磷酸酶水平和骨修复情况。
结果
低强度激光疗法在第7天和18天时显著提高了碱性磷酸酶水平（p<0.001），并在第7天（p<0.01）、18天（p<0.05）和30天（p<0.01）改善了糖尿病动物的骨愈合情况。此外，在第30天时，照射糖尿病组的骨愈合情况与对照组在统计学上相似（p>0.05）。
结论
低强度激光疗法提高了四氧嘧啶诱导的糖尿病大鼠的血清碱性磷酸酶水平并改善了骨愈合情况。
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