Ishiwada Naruhiko, Takeshita Kenichi, Yaguchi Takashi, Nagasawa Koo, Takeuchi Noriko, Hishiki Haruka, Watanabe Akira, Kamei Katsuhiko, Shimojo Naoki
Department of Infectious Diseases, Medical Mycology Research Center, Chiba University, Chiba, Japan.
Department of Pediatrics, Graduate School of Medicine, Chiba University, Chiba, Japan.
Mycopathologia. 2016 Apr;181(3-4):305-9. doi: 10.1007/s11046-015-9963-5. Epub 2015 Nov 13.
A 16-year-old boy with chronic granulomatous disease presented with pneumonia and rib osteomyelitis. Emericella nidulans var. echinulata was isolated from his sputum. After starting voriconazole, Rasamsonia piperina was isolated from the rib swelling. A combination therapy of voriconazole and micafungin effectively eradicated this invasive mixed-mold infection. In immunocompromised patients, a precise pathogenic diagnosis is clinically useful for administration of an appropriate treatment regimen.
一名患有慢性肉芽肿病的16岁男孩出现肺炎和肋骨骨髓炎。从他的痰液中分离出了构巢曲霉棘刺变种。开始使用伏立康唑治疗后，从肋骨肿胀处分离出了胡椒拉斯姆逊菌。伏立康唑和米卡芬净联合治疗有效根除了这种侵袭性混合霉菌感染。在免疫功能低下的患者中，准确的病原学诊断对制定合适的治疗方案具有临床指导意义。
