Tuppurainen E S M, Venter E H, Shisler J L, Gari G, Mekonnen G A, Juleff N, Lyons N A, De Clercq K, Upton C, Bowden T R, Babiuk S, Babiuk L A
Department of Veterinary Biosciences, Faculty of Veterinary Medicine, University of Helsinki, Helsinki, Finland.
Department of Veterinary Tropical Diseases, University of Pretoria, Pretoria, South Africa.
Transbound Emerg Dis. 2017 Jun;64(3):729-745. doi: 10.1111/tbed.12444. Epub 2015 Nov 13.
Lumpy skin disease, sheeppox and goatpox are high-impact diseases of domestic ruminants with a devastating effect on cattle, sheep and goat farming industries in endemic regions. In this article, we review the current geographical distribution, economic impact of an outbreak, epidemiology, transmission and immunity of capripoxvirus. The special focus of the article is to scrutinize the use of currently available vaccines to investigate the resource needs and challenges that will have to be overcome to improve disease control and eradication, and progress on the development of safer and more effective vaccines. In addition, field evaluation of the efficacy of the vaccines and the genomic database available for poxviruses are discussed.
结节性皮肤病、绵羊痘和山羊痘是对家养反刍动物有重大影响的疾病，在流行地区对牛、羊和山羊养殖业具有毁灭性影响。在本文中，我们综述了山羊痘病毒的当前地理分布、疫情的经济影响、流行病学、传播和免疫情况。本文的特别重点是仔细研究当前可用疫苗的使用情况，以调查改善疾病控制和根除所需克服的资源需求和挑战，以及更安全、更有效疫苗的研发进展。此外，还讨论了疫苗效力的现场评估以及痘病毒可用的基因组数据库。
