三唑连接的同碱基DNA的拓扑化学合成

The topochemical synthesis of triazole-linked homobasic DNA.

作者信息

Pathigoolla Atchutarao, Sureshan Kana M

机构信息

School of Chemistry, Indian Institute of Science Education and Research Thiruvananthapuram, Kerala 695016, India.

出版信息

Chem Commun (Camb). 2016 Jan 18;52(5):886-8. doi: 10.1039/c5cc08834h.

DOI:10.1039/c5cc08834h

PMID:26565720

Abstract

Triazolyl-DNA ((TL)DNA), a DNA-analog wherein phosphodiester units are replaced by triazole motifs, is of great interest. We have synthesized (TL)DNA oligomers by adopting the Topochemical Azide-Alkyne Cycloaddition (TAAC) reaction. A nucleoside decorated with the azide and alkyne units crystallized with the proximal placement of the azide and alkyne units of the adjacent molecules and underwent the TAAC reaction to form (TL)DNA oligomers.

摘要

三唑基-DNA（(TL)DNA）是一种将磷酸二酯单元替换为三唑基序的DNA类似物，备受关注。我们通过采用拓扑化学叠氮化物-炔烃环加成（TAAC）反应合成了(TL)DNA低聚物。一种带有叠氮化物和炔烃单元的核苷与相邻分子的叠氮化物和炔烃单元近距离排列结晶，并进行TAAC反应以形成(TL)DNA低聚物。