Nguyen Andrew, Guo James, Banyard Derek A, Fadavi Darya, Toranto Jason D, Wirth Garrett A, Paydar Keyianoosh Z, Evans Gregory R D, Widgerow Alan D
Center for Tissue Engineering, Department of Plastic Surgery, University of California, Irvine, USA.
Department of Plastic Surgery, University of California, Irvine, USA.
J Plast Reconstr Aesthet Surg. 2016 Feb;69(2):170-9. doi: 10.1016/j.bjps.2015.10.015. Epub 2015 Oct 31.
Stromal Vascular Fraction (SVF) is a heterogeneous collection of cells contained within adipose tissue that is traditionally isolated using enzymes such as collagenase. With the removal of adipose cells, connective tissue and blood from lipoaspirate, comes the SVF, a mix including mesenchymal stem cells, endothelial precursor cells, T regulatory cells, macrophages, smooth muscle cells, pericytes and preadipocytes. In part 1 of our 2-part series, we review the literature with regards to the intensifying interest that has shifted toward this mixture of cells, particularly due to its component synergy and translational potential. Trials assessing the regenerative potential of cultured Adipose Derived Stem Cells (ADSCs) and SVF demonstrate that SVF is comparably effective in treating conditions ranging from radiation injuries, burn wounds and diabetes, amongst others. Aside from their use in chronic conditions, SVF enrichment of fat grafts has proven a major advance in maintaining fat graft volume and viability. Many SVF studies are currently in preclinical phases or are moving to human trials. Overall, regenerative cell therapy based on SVF is at an early investigative stage but its potential for clinical application is enormous.
基质血管成分（SVF）是脂肪组织中包含的细胞的异质集合，传统上使用胶原酶等酶进行分离。随着脂肪抽吸物中脂肪细胞、结缔组织和血液的去除，就得到了SVF，它是一种混合物，包括间充质干细胞、内皮祖细胞、调节性T细胞、巨噬细胞、平滑肌细胞、周细胞和前脂肪细胞。在我们这个两部分系列的第1部分中，我们回顾了关于人们对这种细胞混合物兴趣日益浓厚的文献，特别是由于其成分的协同作用和转化潜力。评估培养的脂肪来源干细胞（ADSCs）和SVF再生潜力的试验表明，SVF在治疗辐射损伤、烧伤创面和糖尿病等多种病症方面具有相当的效果。除了用于慢性疾病外，SVF对脂肪移植的富集已被证明是在维持脂肪移植体积和活力方面的一项重大进展。目前许多关于SVF的研究正处于临床前阶段或正在进入人体试验。总体而言，基于SVF的再生细胞疗法尚处于早期研究阶段，但其临床应用潜力巨大。
