Qing Ping, Li Xiao-Lin, Zhang Yan, Li Yi-Lin, Xu Rui-Xia, Guo Yuan-Lin, Li Sha, Wu Na-Qiong, Li Jian-Jun
Division of Dyslipidemia, State Key Laboratory of Cardiovascular Disease, Fu Wai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College, Bei Li Shi Road 167, Beijing, 100037, China.
Department of Cardiology, Xingtai people's hospital, Red Star Street 16, Hebei, 054000, China.
PLoS One. 2015 Nov 13;10(11):e0142458. doi: 10.1371/journal.pone.0142458. eCollection 2015.
The coronary artery calcification (CAC) is clinically considered as one of the important predictors of atherosclerosis. Several studies have confirmed that endothelin-1(ET-1) plays an important role in the process of atherosclerosis formation. The aim of this study was to investigate whether big ET-1 is associated with CAC.
A total of 510 consecutively admitted patients from February 2011 to May 2012 in Fu Wai Hospital were analyzed. All patients had received coronary computed tomography angiography and then divided into two groups based on the results of coronary artery calcium score (CACS). The clinical characteristics including traditional and calcification-related risk factors were collected and plasma big ET-1 level was measured by ELISA. Patients with CAC had significantly elevated big ET-1 level compared with those without CAC (0.5 ± 0.4 vs. 0.2 ± 0.2, P<0.001). In the multivariate analysis, big ET-1 (Tertile 2, HR = 3.09, 95% CI 1.66-5.74, P <0.001, Tertile3 HR = 10.42, 95% CI 3.62-29.99, P<0.001) appeared as an independent predictive factor of the presence of CAC. There was a positive correlation of the big ET-1 level with CACS (r = 0.567, p<0.001). The 10-year Framingham risk (%) was higher in the group with CACS>0 and the highest tertile of big ET-1 (P<0.01). The area under the receiver operating characteristic curve for the big ET-1 level in predicting CAC was 0.83 (95% CI 0.79-0.87, p<0.001), with a sensitivity of 70.6% and specificity of 87.7%.
The data firstly demonstrated that the plasma big ET-1 level was a valuable independent predictor for CAC in our study.
冠状动脉钙化（CAC）在临床上被认为是动脉粥样硬化的重要预测指标之一。多项研究证实，内皮素-1（ET-1）在动脉粥样硬化形成过程中起重要作用。本研究旨在探讨大内皮素-1是否与CAC相关。
分析了2011年2月至2012年5月在阜外医院连续收治的510例患者。所有患者均接受了冠状动脉计算机断层扫描血管造影，并根据冠状动脉钙化积分（CACS）结果分为两组。收集包括传统和钙化相关危险因素在内的临床特征，并采用酶联免疫吸附测定法测量血浆大内皮素-1水平。与无CAC的患者相比，有CAC的患者大内皮素-1水平显著升高（0.5±0.4 vs. 0.2±0.2，P<0.001）。在多变量分析中，大内皮素-1（第二三分位数，HR = 3.09，95%CI 1.66-5.74，P <0.001；第三三分位数，HR = 10.42，95%CI 3.62-29.99，P<0.001）是CAC存在的独立预测因素。大内皮素-1水平与CACS呈正相关（r = 0.567，p<0.001）。CACS>0且大内皮素-1处于最高三分位数的组中，10年弗雷明汉风险（%）更高（P<0.01）。大内皮素-1水平预测CAC的受试者工作特征曲线下面积为0.83（95%CI 0.79-0.87，p<0.001），敏感性为70.6%，特异性为87.7%。
数据首次表明，在我们的研究中，血浆大内皮素-1水平是CAC的一个有价值的独立预测指标。
