Division of Infectious Diseases and Internal Medicine, Fundación Clínica Médica Sur, Mexico City, Mexico Transplantation-Oncology Infectious Diseases Program, Division of Infectious Diseases, Department of Medicine, Weill Cornell Medical Center of Cornell University, New York, New York.
Transplantation-Oncology Infectious Diseases Program, Division of Infectious Diseases, Department of Medicine, Weill Cornell Medical Center of Cornell University, New York, New York.
Clin Infect Dis. 2015 Dec 1;61 Suppl 6:S604-11. doi: 10.1093/cid/civ814.
The echinocandins are large lipopeptide molecules that, since their discovery approximately 41 years ago, have emerged as important additions to the expanding armamentarium against invasive fungal diseases. Echinocandins exert in vitro and in vivo fungicidal action against most Candida species and fungistatic action against Aspergillus species. However, the population of patients at risk for developing invasive fungal infections continues to increase. New therapeutic strategies using echinocandins are needed to improve clinical outcomes in patients with invasive fungal disease.
棘白菌素类是大型脂肽类分子，自大约 41 年前发现以来，已成为对抗侵袭性真菌感染的治疗手段不断扩展的重要补充。棘白菌素类在体外和体内对大多数念珠菌属物种具有杀菌作用，对曲霉属物种具有抑菌作用。然而，有发生侵袭性真菌感染风险的患者人群仍在不断增加。需要使用棘白菌素类的新治疗策略来改善侵袭性真菌感染患者的临床结局。
