Kryczka Jakub, Boncela Joanna
Institute of Medical Biology, Polish Academy of Sciences, 93-232 Lodz, Poland.
Mediators Inflamm. 2015;2015:652035. doi: 10.1155/2015/652035. Epub 2015 Oct 19.
Skin tissue scar formation and fibrosis are often characterized by the increased production and deposition of extracellular matrix components, accompanied by the accumulation of a vast number of myofibroblasts. Scaring is strongly associated with inflammation and wound healing to regain tissue integrity in response to skin tissue injury. However, increased and uncontrolled inflammation, repetitive injury, and individual predisposition might lead to fibrosis, a severe disorder resulting in the formation of dense and stiff tissue that loses the physical properties and physiological functions of normal tissue. Fibrosis is an extremely complicated and multistage process in which bone marrow-derived leukocytes act as both pro- and antifibrotic agents, and therefore, few, if any, effective therapies are available for the most severe and lethal forms of fibrosis. Herein, we discuss the current knowledge on the multidimensional impact of leukocytes on the induction of fibrosis, focusing on skin fibrosis.
皮肤组织瘢痕形成和纤维化的特征通常是细胞外基质成分的产生和沉积增加，并伴有大量肌成纤维细胞的积累。瘢痕形成与炎症和伤口愈合密切相关，以响应皮肤组织损伤从而恢复组织完整性。然而，炎症增加且不受控制、重复性损伤以及个体易感性可能导致纤维化，这是一种严重的病症，会导致形成致密且僵硬的组织，从而丧失正常组织的物理特性和生理功能。纤维化是一个极其复杂的多阶段过程，其中骨髓来源的白细胞既作为促纤维化因子又作为抗纤维化因子，因此，对于最严重和致命形式的纤维化，几乎没有有效的治疗方法。在此，我们讨论关于白细胞对纤维化诱导的多维度影响的当前知识，重点是皮肤纤维化。
